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    STP2 Stp2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856397, updated on 17-May-2024

    Summary

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    Gene symbol
    STP2
    Gene description
    Stp2p
    Primary source
    FungiDB:YHR006W
    Locus tag
    YHR006W
    See related
    SGD:S000001048; AllianceGenome:SGD:S000001048; VEuPathDB:YHR006W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See STP2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (117814..119439)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene protein transporter TIM10 Neighboring gene tRNA-Thr Neighboring gene sterol 14-demethylase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Discovery, validation, and genetic dissection of transcription factor binding sites by comparative and functional genomics. Gertz J, et al. Genome Res, 2005 Aug. PMID 16077013, Free PMC Article
    2. Receptor-mediated endoproteolytic activation of two transcription factors in yeast. Andréasson C, et al. Genes Dev, 2002 Dec 15. PMID 12502738, Free PMC Article
    3. Asi1 is an inner nuclear membrane protein that restricts promoter access of two latent transcription factors. Boban M, et al. J Cell Biol, 2006 Jun 5. PMID 16735580, Free PMC Article
    4. The N-terminal regulatory domain of Stp1p is modular and, fused to an artificial transcription factor, confers full Ssy1p-Ptr3p-Ssy5p sensor control. Andréasson C, et al. Mol Cell Biol, 2004 Sep. PMID 15314160, Free PMC Article
    5. Novel function of transcription factor Uga3 as an activator of branched-chain amino acid permease BAP2 gene expression. Muñoz SA, et al. Microbiology (Reading), 2020 Jan. PMID 31625834

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tup1p bound to the promoter region of TAT1 and TAT2 genes that were dependent on STP1 and STP2 (encoding DNA-binding activator proteins) for expression.
      Title: Yeast Cyc8p and Tup1p proteins function as coactivators for transcription of Stp1/2p-dependent amino acid transporter genes.
    2. Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
      Title: Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
    3. post-whole genome duplication co-conservation of the STP1 and STP2 genes was favored by functional divergence of their products, likely conferring to cells an increased ability to adapt to various amino acid supply conditions.
      Title: Amino acid signaling in yeast: post-genome duplication divergence of the Stp1 and Stp2 transcription factors.
    4. Dal81 indiscriminately amplifies the transactivation potential of both full-length and processed Stp1 and Stp2 by facilitating promoter binding.
      Title: Dal81 enhances Stp1- and Stp2-dependent transcription necessitating negative modulation by inner nuclear membrane protein Asi1 in Saccharomyces cerevisiae.
    5. Asi1, Asi2, and Asi3 work together to maintain the latent properties of transcription factors Stp1 and Stp2
      Title: Inner nuclear membrane proteins Asi1, Asi2, and Asi3 function in concert to maintain the latent properties of transcription factors Stp1 and Stp2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Stp2p
    NP_011870.1
    • Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      117814..119439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179136.1 → NP_011870.1  TPA: Stp2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011870.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKV0, E9P956, P38704
      UniProtKB/TrEMBL
      A0A8H4C171, B3LSC6, C8ZA73
      Conserved Domains (2) summary
      sd00017
      Location:206 → 226
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:204 → 226
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38704.1

    Gene LinkOut

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