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    EFG1 Efg1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853188, updated on 1-Aug-2024

    Summary

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    Gene symbol
    EFG1
    Gene description
    Efg1p
    Primary source
    FungiDB:YGR271C-A
    Locus tag
    YGR271C-A
    See related
    SGD:S000007608; AllianceGenome:SGD:S000007608; VEuPathDB:YGR271C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YGR272C
    Summary
    Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nuclear RNA surveillance; and re-entry into mitotic cell cycle after pheromone arrest. Located in nucleolus. Part of nucleolar preribosome and preribosome, small subunit precursor. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See EFG1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1037800..1038501, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Yta7p Neighboring gene putative RNA helicase Neighboring gene uncharacterized protein Neighboring gene histone acetyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hypoxic adaptation by Efg1 regulates biofilm formation by Candida albicans. Stichternoth C, et al. Appl Environ Microbiol, 2009 Jun. PMID 19346360, Free PMC Article
    2. Systematic screening of polyphosphate (poly P) levels in yeast mutant cells reveals strong interdependence with primary metabolism. Freimoser FM, et al. Genome Biol, 2006. PMID 17107617, Free PMC Article
    3. Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media. Lai LC, et al. Mol Cell Biol, 2005 May. PMID 15870279, Free PMC Article
    4. Genetic interactions of yeast NEP1 (EMG1), encoding an essential factor in ribosome biogenesis. Schilling V, et al. Yeast, 2012 May. PMID 22588997
    5. Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae. Kastenmayer JP, et al. Genome Res, 2006 Mar. PMID 16510898, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Efg1-Bud22 dimer associates with the U14 snoRNP contacting the 5' rRNA domain of an early 90S pre-ribosomal particle.
      Title: The Efg1-Bud22 dimer associates with the U14 snoRNP contacting the 5' rRNA domain of an early 90S pre-ribosomal particle.
    2. Efg1 is a novel, nucleolar ribosome biogenesis factor in Saccharomyces cerevisiae that is directly linked to the surveillance of pre-40S particles.
      Title: Turnover of aberrant pre-40S pre-ribosomal particles is initiated by a novel endonucleolytic decay pathway.
    3. During hypoxia, Efg1 rapidly induced expression of all major classes of genes known to be associated with normoxic biofilm formation.
      Title: Hypoxic adaptation by Efg1 regulates biofilm formation by Candida albicans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear RNA surveillance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in re-entry into mitotic cell cycle after pheromone arrest IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nucleolar preribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, small subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Efg1p
    NP_076891.4
    • Ribosome biogenesis factor required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1037800..1038501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184474.3 → NP_076891.4  TPA: Efg1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_076891.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZUS8, D6VV49, P53328, Q3E705
      UniProtKB/TrEMBL
      B3LHX2, B5VJL4, G2WEZ5, N1P9Z6
      Conserved Domains (1) summary
      pfam10153
      Location:29 → 141
      Efg1; rRNA-processing protein Efg1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E705.2

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