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    PSD2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853080, updated on 11-Sep-2024

    Summary

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    Official Symbol
    PSD2
    Primary source
    SGD:S000003402
    Locus tag
    YGR170W
    See related
    AllianceGenome:SGD:S000003402; FungiDB:YGR170W; VEuPathDB:YGR170W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphatidylserine decarboxylase activity. Involved in phosphatidylcholine biosynthetic process. Located in endosome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (837142..840558)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene pseudouridine synthase PUS6 Neighboring gene Lso2p Neighboring gene methionine--tRNA ligase MSM1 Neighboring gene transporter YIP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reconstitution of phosphatidylserine transport from chemically defined donor membranes to phosphatidylserine decarboxylase 2 implicates specific lipid domains in the process. Wu WI, et al. J Biol Chem, 2004 Feb 20. PMID 14660568
    2. The C2 domain of phosphatidylserine decarboxylase 2 is not required for catalysis but is essential for in vivo function. Kitamura H, et al. J Biol Chem, 2002 Sep 13. PMID 12093819
    3. Cantharidin downregulates PSD1 expression and inhibits autophagic flux in yeast cells. Swagatika S, et al. FEBS Open Bio, 2022 May. PMID 33999504, Free PMC Article
    4. Nonvesicular phospholipid transfer between peroxisomes and the endoplasmic reticulum. Raychaudhuri S, et al. Proc Natl Acad Sci U S A, 2008 Oct 14. PMID 18836080, Free PMC Article
    5. Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae. Bürgermeister M, et al. Biochim Biophys Acta, 2004 Nov 8. PMID 15522832

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase.
      Title: Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase.
    2. results showed that VID22 is required for transcriptional activation of the PSD2 gene.
      Title: VID22 is required for transcriptional activation of the PSD2 gene in the yeast Saccharomyces cerevisiae.
    3. model predicts that this process involves an acceptor membrane complex containing the C2 domains of Psd2p, PstB2p, and Pbi1p that ligate to Scs2p and phosphatidic acid present in the donor membrane
      Title: An assembly of proteins and lipid domains regulates transport of phosphatidylserine to phosphatidylserine decarboxylase 2 in Saccharomyces cerevisiae.
    4. Data demonstrate that loss of Psd2 causes cells to acquire sensitivity to cadmium even though Psd1 remains intact.
      Title: Compartment-specific synthesis of phosphatidylethanolamine is required for normal heavy metal resistance.
    5. mitochondrial biosynthesis of phosphatidylethanolamine is essential for the viability of yeast mutants lacking cardiolipin
      Title: Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine and cardiolipin biosynthetic pathways in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine decarboxylase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycerophospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylethanolamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylserine decarboxylase 2
    NP_011686.1
    • Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      837142..840558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181299.1 → NP_011686.1  TPA: phosphatidylserine decarboxylase 2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011686.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUV4, P53037
      UniProtKB/TrEMBL
      B3LI60, C7GQ77, N1P3V1
      Conserved Domains (3) summary
      cd00030
      Location:19 → 86
      C2; C2 domain
      PLN02964
      Location:523 → 1079
      PLN02964; phosphatidylserine decarboxylase
      NF033845
      Location:276 → 453
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53037.1

    Gene LinkOut

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