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    MIL1 Mil1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850510, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MIL1
    Official Full Name
    Mil1p
    Primary source
    SGD:S000001860
    Locus tag
    YFL034W
    See related
    AllianceGenome:SGD:S000001860; FungiDB:YFL034W; VEuPathDB:YFL034W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables AP-1 adaptor complex binding activity. Involved in clathrin-coated vesicle cargo loading. Is extrinsic component of membrane. Orthologous to human TMCO4 (transmembrane and coiled-coil domains 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MIL1 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (65477..68698)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Mob2p Neighboring gene ribosomal 60S subunit protein L22B Neighboring gene protein kinase RIM15 Neighboring gene transcription factor HAC1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a hypothetical membrane protein interactor of ribosomal phosphoprotein P0. Aruna K, et al. J Biosci, 2004 Mar. PMID 15286401
    2. Acquisition of a stable structure by yeast ribosomal P0 protein requires binding of P1A-P2B complex: in vitro formation of the stalk structure. Krokowski D, et al. Biochim Biophys Acta, 2005 Jun 20. PMID 15866509
    3. The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting. Whitfield ST, et al. Mol Biol Cell, 2016 Feb 1. PMID 26658609, Free PMC Article
    4. Chemogenetic E-MAP in Saccharomyces cerevisiae for Identification of Membrane Transporters Operating Lipid Flip Flop. Vazquez HM, et al. PLoS Genet, 2016 Jul. PMID 27462707, Free PMC Article
    5. The sensitivity of the yeast, Saccharomyces cerevisiae, to acetic acid is influenced by DOM34 and RPL36A. Samanfar B, et al. PeerJ, 2017. PMID 29158977, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mil1 is a predicted lipase that binds Apm2 but not Apm1 and contributes to its membrane recruitment.
      Title: The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables AP-1 adaptor complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin-coated vesicle cargo loading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mil1p
    NP_116583.2
    • Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      65477..68698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179932.2 → NP_116583.2  TPA: Mil1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116583.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTJ7, P43564
      UniProtKB/TrEMBL
      C7GY78, N1P4W0
      Conserved Domains (1) summary
      pfam05277
      Location:541 → 875
      DUF726; Protein of unknown function (DUF726)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43564.2

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