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    ISC10 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856927, updated on 11-Sep-2024

    Summary

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    Official Symbol
    ISC10
    Primary source
    SGD:S000000982
    Locus tag
    YER180C
    See related
    AllianceGenome:SGD:S000000982; FungiDB:YER180C; VEuPathDB:YER180C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mitogen-activated protein kinase binding activity and protein kinase inhibitor activity. Involved in ascospore formation. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (549724..550527, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha Neighboring gene recombinase DMC1 Neighboring gene Slo1p Neighboring gene tRNA-Ile

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a yeast gene that is homologous with a meiosis-specific cDNA from a plant. Kobayashi T, et al. Mol Gen Genet, 1993 Feb. PMID 8455558
    2. Isc10, an inhibitor of the Smk1 MAPK, prevents activation loop autophosphorylation and substrate phosphorylation through separate mechanisms. Rimal A, et al. J Biol Chem, 2022 Oct. PMID 36063999, Free PMC Article
    3. Isc10, an Inhibitor That Links the Anaphase-Promoting Complex to a Meiosis-Specific Mitogen-Activated Protein Kinase. Rimal A, et al. Mol Cell Biol, 2020 Jul 29. PMID 32423992, Free PMC Article
    4. Histone Acetylation, Not Stoichiometry, Regulates Linker Histone Binding in Saccharomyces cerevisiae. Lawrence MBD, et al. Genetics, 2017 Sep. PMID 28739661, Free PMC Article
    5. The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Dietrich FS, et al. Nature, 1997 May 29. PMID 9169868, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Isc10, an Inhibitor That Links the Anaphase-Promoting Complex to a Meiosis-Specific Mitogen-Activated Protein Kinase.
      Title: Isc10, an Inhibitor That Links the Anaphase-Promoting Complex to a Meiosis-Specific Mitogen-Activated Protein Kinase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mitogen-activated protein kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Isc10p
    NP_011107.1
    • Meiosis-specific MAPK inhibitor; binds Smk1p during meiosis I; links APC/C-Ama1 to Smk1p activation; required for sporulation; transcript is induced 7.5 hr after induction of meiosis; Isc10p is ubiquitylated and degraded in an Ama1p-dependent manner upon completion of meiosis II

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      549724..550527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179070.1 → NP_011107.1  TPA: Isc10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011107.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM89, P32645
      UniProtKB/TrEMBL
      G2WD67
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32645.1

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