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    SPO73 Spo73p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856770, updated on 17-May-2024

    Summary

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    Gene symbol
    SPO73
    Gene description
    Spo73p
    Primary source
    FungiDB:YER046W
    Locus tag
    YER046W
    See related
    SGD:S000000848; AllianceGenome:SGD:S000000848; VEuPathDB:YER046W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in ascospore wall assembly and ascospore-type prospore membrane formation. Located in cytosol and prospore membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SPO73 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (243180..243611)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Mei4p Neighboring gene Aca1p Neighboring gene putative AAA family ATPase SAP1 Neighboring gene Caj1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Dysferlin Domain-Only Protein, Spo73, Is Required for Prospore Membrane Extension in Saccharomyces cerevisiae. Okumura Y, et al. mSphere, 2016 Jan-Feb. PMID 27303688, Free PMC Article
    2. SPO73 and SPO71 Function Cooperatively in Prospore Membrane Elongation During Sporulation in Saccharomyces cerevisiae. Parodi EM, et al. PLoS One, 2015. PMID 26605945, Free PMC Article
    3. Dynamic localization of a yeast development-specific PP1 complex during prospore membrane formation is dependent on multiple localization signals and complex formation. Nakamura TS, et al. Mol Biol Cell, 2017 Dec 15. PMID 29046399, Free PMC Article
    4. Suppression of Vps13 adaptor protein mutants reveals a central role for PI4P in regulating prospore membrane extension. Nakamura TS, et al. PLoS Genet, 2021 Aug. PMID 34407079, Free PMC Article
    5. A screen for genes required for meiosis and spore formation based on whole-genome expression. Rabitsch KP, et al. Curr Biol, 2001 Jul 10. PMID 11470404

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ascospore wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ascospore-type prospore membrane formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in prospore membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Spo73p
    NP_010965.1
    • Meiosis-specific protein required for prospore membrane morphogenesis; required for the proper shape of the prospore membrane (PSM) and for spore wall formation; functions cooperatively with SPO71 in PSM elongation; physically interacts with Spo71p; genetically antagonistic to SPO1, similar to SPO71; localizes to the PSM; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; dysferlin domain-only protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      243180..243611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178937.1 → NP_010965.1  TPA: Spo73p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010965.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLU7, P40031
      UniProtKB/TrEMBL
      A0A6A5PX44, A6ZQZ6, B3LS59, C7GSJ4, G2WCT0, N1PA38
      Conserved Domains (1) summary
      smart00694
      Location:108 → 139
      DysFC; Dysferlin domain, C-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40031.1

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