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    ARB1 ATP-binding cassette family ATPase ARB1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856758, updated on 7-Jul-2024

    Summary

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    Gene symbol
    ARB1
    Gene description
    ATP-binding cassette family ATPase ARB1
    Primary source
    FungiDB:YER036C
    Locus tag
    YER036C
    See related
    SGD:S000000838; AllianceGenome:SGD:S000000838; VEuPathDB:YER036C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATP hydrolysis activity. Involved in ribosomal small subunit export from nucleus. Acts upstream of or within protein unfolding. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ARB1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (223367..225199, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Edc2p Neighboring gene bifunctional nucleotidase/lysophosphatidic acid phosphatase Neighboring gene Smc5-Smc6 complex subunit KRE29

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ABCF gene family facilitates disaggregation during animal development. Skuodas S, et al. Mol Biol Cell, 2020 Jun 15. PMID 32320318, Free PMC Article
    2. Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis. Su T, et al. Nature, 2019 Jun. PMID 31189955
    3. Cbk1p, a protein similar to the human myotonic dystrophy kinase, is essential for normal morphogenesis in Saccharomyces cerevisiae. Racki WJ, et al. EMBO J, 2000 Sep 1. PMID 10970846, Free PMC Article
    4. The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation. Gómez-Herreros F, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28637236, Free PMC Article
    5. The novel ATP-binding cassette protein ARB1 is a shuttling factor that stimulates 40S and 60S ribosome biogenesis. Dong J, et al. Mol Cell Biol, 2005 Nov. PMID 16260602, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. structure and function of Vms1 and Arb1 in ribosome-associated quality control (RQC) and mitochondrial proteome homeostasis
      Title: Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.
    2. ARB1 functions as a mechanochemical ATPase to stimulate multiple steps in the 40S and 60S ribosomal biogenesis pathways
      Title: The novel ATP-binding cassette protein ARB1 is a shuttling factor that stimulates 40S and 60S ribosome biogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein unfolding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette family ATPase ARB1
    NP_010953.1
    • ATPase of the ATP-binding cassette (ABC) family; involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; important for disaggregation of ordered and disordered aggregates; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p; human homolog ABCF2 can complement yeast ARB1 mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      223367..225199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178927.1 → NP_010953.1  TPA: ATP-binding cassette family ATPase ARB1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010953.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLT5, P40024
      UniProtKB/TrEMBL
      A0A6A5PWE0, A6ZQY5, B3LS48, B5VHH1, C8Z738, G2WCR9, N1P4S7
      Conserved Domains (1) summary
      COG0488
      Location:79 → 601
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40024.1

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