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    MXR1 peptide-methionine-S-sulfoxide reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856765, updated on 4-Aug-2024

    Summary

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    Gene symbol
    MXR1
    Gene description
    peptide-methionine-S-sulfoxide reductase
    Primary source
    FungiDB:YER042W
    Locus tag
    YER042W
    See related
    SGD:S000000844; AllianceGenome:SGD:S000000844; VEuPathDB:YER042W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables peptide-methionine (S)-S-oxide reductase activity. Involved in cellular response to oxidative stress. Located in cytoplasm. Orthologous to human MSRA (methionine sulfoxide reductase A). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MXR1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (234937..235491)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene nitrogen-responsive transcriptional regulator GLN3 Neighboring gene crossover junction endodeoxyribonuclease Neighboring gene adenosylhomocysteinase Neighboring gene Erg28p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein-carbonyl accumulation in the non-replicative senescence of the methionine sulfoxide reductase A (msrA) knockout yeast strain. Oien D, et al. Amino Acids, 2007. PMID 17077964
    2. The yeast cytosolic thioredoxins are involved in the regulation of methionine sulfoxide reductase A. Hanbauer I, et al. Free Radic Biol Med, 2006 Apr 15. PMID 16631529
    3. The level of MXR1 gene expression in brewing yeast during beer fermentation is a major determinant for the concentration of dimethyl sulfide in beer. Hansen J, et al. FEMS Yeast Res, 2002 May. PMID 12702301
    4. Identification and characterization of a putative active site for peptide methionine sulfoxide reductase (MsrA) and its substrate stereospecificity. Moskovitz J, et al. J Biol Chem, 2000 May 12. PMID 10799493
    5. Inactivation of MXR1 abolishes formation of dimethyl sulfide from dimethyl sulfoxide in Saccharomyces cerevisiae. Hansen J. Appl Environ Microbiol, 1999 Sep. PMID 10473395, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the plasticity of the Trx binding site on Mxr1 provides structural insights into the recognition of diverse substrates by a universal catalytic motif of Trx.
      Title: Structural plasticity of the thioredoxin recognition site of yeast methionine S-sulfoxide reductase Mxr1.
    2. Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae.
      Title: Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae.
    3. MSRA and MSRB helps to preserve the function of cellular FeS clusters from oxidative inactivation.
      Title: Methionine sulphoxide reductases protect iron-sulphur clusters from oxidative inactivation in yeast.
    4. interacts with glutathione peroxidase Gpx3; Gpx3 functions as a redox-dependent exquisite regulator of the protein repair activity of Mxr1
      Title: Glutathione peroxidase 3 of Saccharomyces cerevisiae regulates the activity of methionine sulfoxide reductase in a redox state-dependent way.
    5. under normal growth conditions thioredoxin 1 is essential for msrA transcription and activity
      Title: The yeast cytosolic thioredoxins are involved in the regulation of methionine sulfoxide reductase A.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-methionine-(S)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-methionine (S)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (S)-S-oxide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-methionine (S)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-methionine (S)-S-oxide reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    peptide-methionine-S-sulfoxide reductase
    NP_010960.1
    • Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      234937..235491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178933.1 → NP_010960.1  TPA: peptide-methionine-S-sulfoxide reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010960.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLU2, P40029
      UniProtKB/TrEMBL
      A6ZQZ1, B3LS55, C7GSI9, C8Z745, G2WCS5, N1PA37
      Conserved Domains (1) summary
      TIGR00401
      Location:17 → 171
      msrA; methionine-S-sulfoxide reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40029.1

    Gene LinkOut

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