RPN3 proteasome regulatory particle lid subunit RPN3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: RPN3
Gene description: proteasome regulatory particle lid subunit RPN3
Primary source: FungiDB:YER021W
Locus tag: YER021W
See related: SGD:S000000823; AllianceGenome:SGD:S000000823; VEuPathDB:YER021W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SUN2
Summary: Predicted to enable enzyme regulator activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle, lid subcomplex. Orthologous to human PSMD3 (proteasome 26S subunit, non-ATPase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RPN3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (196948..198519)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the availability of Rpn11 is important for maintaining adequate levels of intact proteasomes, as its depletion caused growth and proteolytic defects in rpn3.
Title: A proteasome assembly defect in rpn3 mutants is associated with Rpn11 instability and increased sensitivity to stress.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, lid subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, lid subcomplex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, lid subcomplex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome regulatory particle lid subunit RPN3

NP_010938.1

Essential non-ATPase regulatory subunit of the 26S proteasome lid; similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

196948..198519

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178912.1 → NP_010938.1 TPA: proteasome regulatory particle lid subunit RPN3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010938.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLS0, P40016

UniProtKB/TrEMBL

A6ZQX0, G2WCQ4, N1P5S1

Conserved Domains (2) summary

pfam01399
Location:343 → 447

PCI; PCI domain

pfam08375
Location:450 → 509

Rpn3_C; Proteasome regulatory subunit C-terminal