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    GNP1 glutamine permease GNP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852121, updated on 1-Aug-2024

    Summary

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    Gene symbol
    GNP1
    Gene description
    glutamine permease GNP1
    Primary source
    FungiDB:YDR508C
    Locus tag
    YDR508C
    See related
    SGD:S000002916; AllianceGenome:SGD:S000002916; VEuPathDB:YDR508C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables L-proline transmembrane transporter activity. Involved in cellular sphingolipid homeostasis and serine import across plasma membrane. Located in several cellular components, including cellular bud neck; endoplasmic reticulum; and mitochondrion. Human ortholog(s) of this gene implicated in cystinuria; lysinuric protein intolerance; and retinitis pigmentosa 68. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A14 (solute carrier family 7 member 14); and SLC7A2 (solute carrier family 7 member 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GNP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1466453..1468444, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene protein kinase GIN4 Neighboring gene SUMO family protein SMT3 Neighboring gene Sdh7p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GNP1, the high-affinity glutamine permease of S. cerevisiae. Zhu X, et al. Curr Genet, 1996 Jul 31. PMID 8660458
    2. Genome-wide expression analysis of genes affected by amino acid sensor Ssy1p in Saccharomyces cerevisiae. Kodama Y, et al. Curr Genet, 2002 May. PMID 12073087
    3. Amino acid residues important for substrate specificity of the amino acid permeases Can1p and Gnp1p in Saccharomyces cerevisiae. Regenberg B, et al. Yeast, 2001 Nov. PMID 11746604
    4. Four permeases import proline and the toxic proline analogue azetidine-2-carboxylate into yeast. Andréasson C, et al. Yeast, 2004 Feb. PMID 14968425
    5. Effect of the deubiquitination enzyme gene UBP6 on the stress-responsive transcription factor Msn2-mediated control of the amino acid permease Gnp1 in yeast. Mat Nanyan NSB, et al. J Biosci Bioeng, 2020 Apr. PMID 31640922

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae.
      Title: Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae.
    2. An excess level of Msn2 impairs endocytic degradation of Gnp1 through dysfunction of Ubp6 and other deubiquitinating enzymes.
      Title: Effect of the deubiquitination enzyme gene UBP6 on the stress-responsive transcription factor Msn2-mediated control of the amino acid permease Gnp1 in yeast.
    3. Using in silico analyses and mutational studies we found that the C-terminal sequences of Gap1, Bap2, Hip1, Tat1, Tat2, Mmp1, Sam3, Agp1, and Gnp1 are about 50 residues long, associate with the Plasma Membrane , and have features that discriminate them from the termini of organellar amino acid transporters
      Title: A Plasma Membrane Association Module in Yeast Amino Acid Transporters.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-proline transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular sphingolipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proline transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in serine import across plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in serine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamine permease GNP1
    NP_010796.1
    • Broad specificity amino acid permease; high-affinity glutamine permease; major serine permease with minor contributions from paralog Agp1p; role in serine uptake impacts cellular sphingolipid homeostasis; also transports Leu, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1466453..1468444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180816.1 → NP_010796.1  TPA: glutamine permease GNP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010796.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTD0, P48813
      UniProtKB/TrEMBL
      G2WBN6, N1P7H3
      Conserved Domains (1) summary
      TIGR00913
      Location:146 → 626
      2A0310; amino acid permease (yeast)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48813.2

    Gene LinkOut

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