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    SHM1 glycine hydroxymethyltransferase SHM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852565, updated on 29-Jun-2024

    Summary

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    Gene symbol
    SHM1
    Gene description
    glycine hydroxymethyltransferase SHM1
    Primary source
    FungiDB:YBR263W
    Locus tag
    YBR263W
    See related
    SGD:S000000467; AllianceGenome:SGD:S000000467; VEuPathDB:YBR263W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SHMT1; TMP3
    Summary
    Enables glycine hydroxymethyltransferase activity. Involved in one-carbon metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human SHMT1 (serine hydroxymethyltransferase 1) and SHMT2 (serine hydroxymethyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SHM1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (736264..737736)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene N-terminal protein methyltransferase Neighboring gene Mic12p Neighboring gene Rab family GTPase YPT10 Neighboring gene 3-dehydrosphinganine reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of the genes encoding the serine hydroxymethyltransferases from Saccharomyces cerevisiae. Taylor BV, et al. Adv Exp Med Biol, 1993. PMID 8304212
    2. Isolation and properties of a thymidylate-less mutant in Saccharomyces cerevisiae. Luzzati M. Eur J Biochem, 1975 Aug 15. PMID 1100397
    3. Mitochondrial and cytoplasmic distribution in Saccharmoyces cerevisiae of enzymes involved in folate-coenzyme-mediated one-carbon-group transfer. A genetic and biochemical study of the enzyme deficiencies in mutants tmp3 and ade3. Zelikson R, et al. Eur J Biochem, 1977 Sep 15. PMID 334546
    4. Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae. Kastanos EK, et al. Biochemistry, 1997 Dec 2. PMID 9398220
    5. Two forms of serine transhydroxymethylase, one absent in a thymidylate-less mutant in Saccharomyces cerevisiae. Zelikson R, et al. Eur J Biochem, 1976 Apr 15. PMID 6271

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycine hydroxymethyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine hydroxymethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycine hydroxymethyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycine biosynthetic process from serine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in one-carbon metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in one-carbon metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycine hydroxymethyltransferase SHM1
    NP_009822.4
    • Mitochondrial serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      736264..737736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178611.3 → NP_009822.4  TPA: glycine hydroxymethyltransferase SHM1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009822.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQR0, P37292
      UniProtKB/TrEMBL
      A0A8H4BVI8, A6ZLK3, B3LMP8, C7GMW7, D3UF11, G2W9R8, N1P767
      Conserved Domains (1) summary
      pfam00464
      Location:33 → 432
      SHMT; Serine hydroxymethyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37292.2

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