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    EXO5 Exo5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852461, updated on 1-Aug-2024

    Summary

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    Gene symbol
    EXO5
    Gene description
    Exo5p
    Primary source
    FungiDB:YBR163W
    Locus tag
    YBR163W
    See related
    SGD:S000000367; AllianceGenome:SGD:S000000367; VEuPathDB:YBR163W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DEM1
    Summary
    Enables single-stranded DNA 5'-3' exodeoxyribonuclease activity. Involved in mitochondrial genome maintenance. Located in mitochondrion. Orthologous to human EXO5 (exonuclease 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See EXO5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (565723..567480)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Tos1p Neighboring gene Ysy6p Neighboring gene Arf family GTPase ARL1 Neighboring gene Ubs1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast exonuclease 5 is essential for mitochondrial genome maintenance. Burgers PM, et al. Mol Cell Biol, 2010 Mar. PMID 20086101, Free PMC Article
    2. Detection of eQTL modules mediated by activity levels of transcription factors. Sun W, et al. Bioinformatics, 2007 Sep 1. PMID 17599927
    3. Exonuclease V from Saccharomyces cerevisiae. A 5'----3'-deoxyribonuclease that produces dinucleotides in a sequential fashion. Burgers PM, et al. J Biol Chem, 1988 Jun 15. PMID 3286646
    4. Scan statistics analysis for detection of introns in time-course tiling array data. Reiner-Benaim A, et al. Stat Appl Genet Mol Biol, 2014 Apr 1. PMID 24572987
    5. Human exonuclease 5 is a novel sliding exonuclease required for genome stability. Sparks JL, et al. J Biol Chem, 2012 Dec 14. PMID 23095756, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA 5'-3' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA 5'-3' DNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA 5'-3' DNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial genome maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial genome maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Exo5p
    NP_009722.3
    • Mitochondrial 5'-3' exonuclease and sliding exonuclease; required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      565723..567480
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178511.3 → NP_009722.3  TPA: Exo5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009722.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQF9, P38289
      UniProtKB/TrEMBL
      G2W9G6, N1P8B3
      Conserved Domains (1) summary
      pfam09810
      Location:126 → 560
      Exo5; Exonuclease V - a 5' deoxyribonuclease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38289.1

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