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    TRM7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852353, updated on 11-Sep-2024

    Summary

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    Official Symbol
    TRM7
    Primary source
    SGD:S000000265
    Locus tag
    YBR061C
    See related
    AllianceGenome:SGD:S000000265; FungiDB:YBR061C; VEuPathDB:YBR061C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA 2'-O-methyltransferase activity. Involved in cytoplasmic translation and wobble position ribose methylation. Located in cytoplasm. Used to study non-syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 9. Orthologous to human FTSJ1 (FtsJ RNA 2'-O-methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (364787..365719, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase AKL1 Neighboring gene origin recognition complex subunit 2 Neighboring gene uncharacterized protein Neighboring gene Cnm1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast Saccharomyces cerevisiae YDL112w ORF encodes the putative 2'-O-ribose methyltransferase catalyzing the formation of Gm18 in tRNAs. Cavaillé J, et al. RNA, 1999 Jan. PMID 9917067, Free PMC Article
    2. Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition. Hirata A, et al. Nucleic Acids Res, 2019 Nov 18. PMID 31586407, Free PMC Article
    3. Defects in tRNA Anticodon Loop 2'-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations in FTSJ1. Guy MP, et al. Hum Mutat, 2015 Dec. PMID 26310293, Free PMC Article
    4. Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop. Pintard L, et al. EMBO J, 2002 Apr 2. PMID 11927565, Free PMC Article
    5. A novel assay provides insight into tRNAPhe retrograde nuclear import and re-export in S. cerevisiae. Nostramo RT, et al. Nucleic Acids Res, 2020 Nov 18. PMID 33074312, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.
      Title: Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (cytidine(32)-2'-O)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (cytidine) methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(34)-2'-O)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA 2'-O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA nucleoside ribose methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA nucleoside ribose methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wobble position ribose methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in wobble position ribose methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA methyltransferase TRM7
    NP_009617.3
    • 2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively; yeast null mutant can be functionally complemented by human FTSJ1, mutations in which have been implicated in nonsyndromic X-linked intellectual disability (NSXLID)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      364787..365719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178409.3 → NP_009617.3  TPA: tRNA methyltransferase TRM7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009617.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ61, P38238
      UniProtKB/TrEMBL
      A6ZL06, B3LN87, B5VE27, C7GQH7, D3UEF9, G2W967, N1P9D8
      Conserved Domains (1) summary
      COG0293
      Location:1 → 211
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38238.1

    Gene LinkOut

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