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    PRP6 U4/U6-U5 snRNP complex subunit PRP6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852344, updated on 1-Aug-2024

    Summary

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    Gene symbol
    PRP6
    Gene description
    U4/U6-U5 snRNP complex subunit PRP6
    Primary source
    FungiDB:YBR055C
    Locus tag
    YBR055C
    See related
    SGD:S000000259; AllianceGenome:SGD:S000000259; VEuPathDB:YBR055C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RNA6; TSM7269
    Summary
    Involved in mRNA splicing, via spliceosome. Part of U4/U6 snRNP and U4/U6 x U5 tri-snRNP complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa 60. Orthologous to human PRPF6 (pre-mRNA processing factor 6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PRP6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (344602..347301, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Yro2p Neighboring gene tRNA-Leu Neighboring gene 17-beta-hydroxysteroid dehydrogenase-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The biochemical defects of prp4-1 and prp6-1 yeast splicing mutants reveal that the PRP6 protein is required for the accumulation of the [U4/U6.U5] tri-snRNP. Galisson F, et al. Nucleic Acids Res, 1993 Apr 11. PMID 8479905, Free PMC Article
    2. Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm. Legrain P, et al. Cell, 1989 May 19. PMID 2655924
    3. Isolation of S. cerevisiae snRNPs: comparison of U1 and U4/U6.U5 to their human counterparts. Fabrizio P, et al. Science, 1994 Apr 8. PMID 8146658
    4. The yeast PRP6 gene encodes a U4/U6 small nuclear ribonucleoprotein particle (snRNP) protein, and the PRP9 gene encodes a protein required for U2 snRNP binding. Abovich N, et al. Mol Cell Biol, 1990 Dec. PMID 2147224, Free PMC Article
    5. The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors. Legrain P, et al. EMBO J, 1990 Sep. PMID 2118103, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U4/U6-U5 snRNP complex subunit PRP6
    NP_009611.1
    • Splicing factor; component of the U4/U6-U5 snRNP complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      344602..347301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178403.1 → NP_009611.1  TPA: U4/U6-U5 snRNP complex subunit PRP6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009611.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ54, P19735
      UniProtKB/TrEMBL
      A6ZKZ8, B3LN94, D3UEF0, N1P9D6
      Conserved Domains (4) summary
      TIGR02917
      Location:609 → 831
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:668 → 696
      TPR; TPR repeat [structural motif]
      pfam06424
      Location:11 → 131
      PRP1_N; PRP1 splicing factor, N-terminal
      cl26712
      Location:201 → 370
      U3_assoc_6; U3 small nucleolar RNA-associated protein 6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19735.1

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