NUP1 FG-nucleoporin NUP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: NUP1
Gene description: FG-nucleoporin NUP1
Primary source: FungiDB:YOR098C
Locus tag: YOR098C
See related: SGD:S000005624; AllianceGenome:SGD:S000005624; VEuPathDB:YOR098C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: A structural constituent of nuclear pore. Involved in nucleocytoplasmic transport and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Part of nuclear pore central transport channel and nuclear pore nuclear basket. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NUP1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (507948..511178, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Co-translational assembly and localized translation of nucleoporins in nuclear pore complex biogenesis.
Title: Co-translational assembly and localized translation of nucleoporins in nuclear pore complex biogenesis.
fusing a DNA binding domain to the Nuclear Pore Complex basket protein Nup1 reduces telomere relocalization to nuclear pores early after telomerase inactivation. This Nup1 modification also impairs the relocalization to the Nuclear Pore Complex of expanded CAG/CTG triplet repeats.
Title: The nuclear pore complex prevents sister chromatid recombination during replicative senescence.
high levels of the Nup1/Nup60 amphipathic helices cause deformation of the yeast nuclear membrane
Title: Nuclear pore basket proteins are tethered to the nuclear envelope and can regulate membrane curvature.
a novel functional connection between Nup1 and proteins comprising both the spindle pole body and early mitotic exit network
Title: Mutations affecting spindle pole body and mitotic exit network function are synthetically lethal with a deletion of the nucleoporin NUP1 in S. cerevisiae.
Although full-length Nup1p or Nup153 does not complement Nup124p, the functionality of their conserved domains with reference to Tf1 activity suggests that these three proteins evolved from a common ancestor.
Title: Multiple conserved domains of the nucleoporin Nup124p and its orthologs Nup1p and Nup153 are critical for nuclear import and activity of the fission yeast Tf1 retrotransposon.
Pom152 mutants lacking N-linked glycosylation sites are viable in combination with nup1Delta, suppress nup1Delta temperature sensitivity, and partially suppress the nuclear protein import defects associated with the deletion of NUP1.
Title: Nuclear pore complex function in Saccharomyces cerevisiae is influenced by glycosylation of the transmembrane nucleoporin Pom152p.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of nuclear pore	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in NLS-bearing protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in poly(A)+ mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore central transport channel	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore nuclear basket	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FG-nucleoporin NUP1

NP_014741.1

FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of thenuclear pore complex (NPC) permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

507948..511178 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183517.1 → NP_014741.1 TPA: FG-nucleoporin NUP1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014741.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2F9, P20676

UniProtKB/TrEMBL

G2WMX5, N1P335

Conserved Domains (3) summary

COG5651
Location:737 → 1053

COG5651; PPE-repeat protein [Function unknown]

PTZ00108
Location:458 → 690

PTZ00108; DNA topoisomerase 2-like protein; Provisional

PTZ00482
Location:302 → 490

PTZ00482; membrane-attack complex/perforin (MACPF) Superfamily; Provisional