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    SFH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851032, updated on 11-Sep-2024

    Summary

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    Official Symbol
    SFH1
    Primary source
    SGD:S000004313
    Locus tag
    YLR321C
    See related
    AllianceGenome:SGD:S000004313; FungiDB:YLR321C; VEuPathDB:YLR321C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable transcription coregulator activity. Involved in several processes, including chromatin remodeling; nucleic acid metabolic process; and regulation of nuclear cell cycle DNA replication. Part of RSC-type complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 3; atypical teratoid rhabdoid tumor; neurilemmomatosis; and rhabdoid cancer. Orthologous to human SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (776584..777864, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Bud6p Neighboring gene Mms22p Neighboring gene U2-type spliceosomal complex subunit CWC24 Neighboring gene peroxisome biogenesis protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sec14-like phosphatidylinositol-transfer proteins and diversification of phosphoinositide signalling outcomes. Tripathi A, et al. Biochem Soc Trans, 2014 Oct. PMID 25233419, Free PMC Article
    2. Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution. Schaaf G, et al. Mol Biol Cell, 2011 Mar 15. PMID 21248202, Free PMC Article
    3. Complementation analyses suggest species-specific functions of the SNF5 homology domain. Bonazzi V, et al. Biochem Biophys Res Commun, 2005 Oct 21. PMID 16154112
    4. Abundance of the RSC nucleosome-remodeling complex is important for the cells to tolerate DNA damage in Saccharomyces cerevisiae. Koyama H, et al. FEBS Lett, 2002 Nov 6. PMID 12417315
    5. Sfh1p, a component of a novel chromatin-remodeling complex, is required for cell cycle progression. Cao Y, et al. Mol Cell Biol, 1997 Jun. PMID 9154831, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a model that Sfh1 promotes phosphatidylethanolamine production by Psd2 by transferring phospholipids between the ER and endosome.
      Title: Suppression of respiratory growth defect of mitochondrial phosphatidylserine decarboxylase deficient mutant by overproduction of Sfh1, a Sec14 homolog, in yeast.
    2. Data suggest that SFH1 and SEC14L undergo conformational changes as phosphatidylinositol/phosphatidylcholine bind to hydrophobic pockets/ligand binding sites. [review-like article]
      Title: Sec14-like phosphatidylinositol-transfer proteins and diversification of phosphoinositide signalling outcomes.
    3. Results identify mutations that confer Sec14-like activities to a functionally inert pseudo-Sec14 (Sfh1), which seemingly conserves all of the structural requirements for Sec14 function.
      Title: Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nucleosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling at centromere IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of nuclear cell cycle DNA replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RSC-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RSC-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sfh1p
    NP_013425.1
    • Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog; hSNF5 tumor suppressor ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      776584..777864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182210.1 → NP_013425.1  TPA: Sfh1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013425.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYW4, Q06168
      UniProtKB/TrEMBL
      A7A1K5, B3RHJ7, B5VNL7, C7GUB2, G2WJE3, N1NZM1
      Conserved Domains (1) summary
      pfam04855
      Location:204 → 391
      SNF5; SNF5 / SMARCB1 / INI1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06168.1

    Gene LinkOut

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