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    CNPY1 canopy FGF signaling regulator 1 [ Homo sapiens (human) ]

    Gene ID: 285888, updated on 17-Sep-2024

    Summary

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    Official Symbol
    CNPY1provided by HGNC
    Official Full Name
    canopy FGF signaling regulator 1provided by HGNC
    Primary source
    HGNC:HGNC:27786
    See related
    Ensembl:ENSG00000146910 MIM:612493; AllianceGenome:HGNC:27786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Cnpy1 is expressed in the midbrain-hindbrain (MHB) boundary in zebrafish, binds FGFR1 (MIM 136350), and plays a role in FGF signaling (Hirate and Okamoto, 2006 [PubMed 16488878]).[supplied by OMIM, Dec 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See CNPY1 in Genome Data Viewer
    Location:
    7q36.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (155501129..155546559, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (156681736..156727153, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (155293824..155339254, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr7:155233227-155233442 Neighboring gene EN2 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:155246511-155247036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:155247037-155247562 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:155249486-155250477 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:155262299-155262494 Neighboring gene VISTA enhancer hs1418 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:155274926-155276125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:155277075-155277575 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:155282581-155283314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18847 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:155286713-155287262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:155290079-155290782 Neighboring gene engrailed homeobox 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18848 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:155301523-155302370 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:155302371-155303216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:155334782-155335582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:155340869-155341370 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:155382158-155382978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:155386984-155387730 Neighboring gene Sharpr-MPRA regulatory region 10004 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:155436294-155437248 Neighboring gene RBM33 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26899 Neighboring gene RNA binding motif protein 33 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:155520719-155521219 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:155534138-155535337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26901 Neighboring gene VISTA enhancer hs1268 Neighboring gene Sharpr-MPRA regulatory region 9615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26902 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:155561116-155561309 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:155567610-155568809 Neighboring gene Sharpr-MPRA regulatory region 3765

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafish. Hirate Y, et al. Curr Biol, 2006 Feb 21. PMID 16488878
    2. Human chromosome 7: DNA sequence and biology. Scherer SW, et al. Science, 2003 May 2. PMID 12690205, Free PMC Article
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125606

    General protein information

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    Preferred Names
    protein canopy homolog 1
    Names
    canopy 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103176.2 → NP_001096646.1  protein canopy homolog 1 isoform b

      See identical proteins and their annotated locations for NP_001096646.1

      Status: VALIDATED

      Source sequence(s)
      AC008060, AC009403
      Consensus CDS
      CCDS43684.1
      UniProtKB/Swiss-Prot
      A6NGX3, Q3B7I2
      Related
      ENSP00000317439.5, ENST00000321736.5
      Conserved Domains (1) summary
      pfam11938
      Location:1 → 77
      DUF3456; TLR4 regulator and MIR-interacting MSAP

    2. NM_001369814.1 → NP_001356743.1  protein canopy homolog 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC008060, AC009403
      Consensus CDS
      CCDS43684.1
      UniProtKB/Swiss-Prot
      A6NGX3, Q3B7I2
      Conserved Domains (1) summary
      pfam11938
      Location:1 → 77
      DUF3456; TLR4 regulator and MIR-interacting MSAP

    3. NM_001369815.1 → NP_001356744.1  protein canopy homolog 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC008060
      Consensus CDS
      CCDS43684.1
      UniProtKB/Swiss-Prot
      A6NGX3, Q3B7I2
      Conserved Domains (1) summary
      pfam11938
      Location:1 → 77
      DUF3456; TLR4 regulator and MIR-interacting MSAP

    4. NM_001369816.1 → NP_001356745.1  protein canopy homolog 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC008060
      Consensus CDS
      CCDS43684.1
      UniProtKB/Swiss-Prot
      A6NGX3, Q3B7I2
      Conserved Domains (1) summary
      pfam11938
      Location:1 → 77
      DUF3456; TLR4 regulator and MIR-interacting MSAP

    5. NM_001369818.2 → NP_001356747.2  protein canopy homolog 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC008060
      Consensus CDS
      CCDS43684.1
      UniProtKB/Swiss-Prot
      A6NGX3, Q3B7I2
      Conserved Domains (1) summary
      pfam11938
      Location:1 → 77
      DUF3456; TLR4 regulator and MIR-interacting MSAP

    6. NM_001369820.1 → NP_001356749.1  protein canopy homolog 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC008060
      Consensus CDS
      CCDS43684.1
      UniProtKB/Swiss-Prot
      A6NGX3, Q3B7I2
      Conserved Domains (1) summary
      pfam11938
      Location:1 → 77
      DUF3456; TLR4 regulator and MIR-interacting MSAP

    7. NM_001369821.1 → NP_001356750.1  protein canopy homolog 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC008060
      Consensus CDS
      CCDS43684.1
      UniProtKB/Swiss-Prot
      A6NGX3, Q3B7I2
      Conserved Domains (1) summary
      pfam11938
      Location:1 → 77
      DUF3456; TLR4 regulator and MIR-interacting MSAP

    8. NM_001393663.1 → NP_001380592.1  protein canopy homolog 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20) encodes the longer isoform (a).
      Source sequence(s)
      AC008060, AC009403
      Consensus CDS
      CCDS94241.1
      UniProtKB/TrEMBL
      A0A1B0GUD4, A0A1B0GVE0
      Related
      ENSP00000490477.3, ENST00000636446.2

    RNA

    1. NR_163157.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008060, AC009403

    2. NR_163158.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008060, AC009403

    3. NR_163159.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008060

    4. NR_163160.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008060
      Related
      ENST00000682997.2

    5. NR_163161.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008060

    6. NR_163162.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008060

    7. NR_163163.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008060

    8. NR_163164.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008060

    9. NR_163165.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008060

    10. NR_163166.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008060

    11. NR_163167.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008060

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      155501129..155546559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      156681736..156727153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001369813.1: Suppressed sequence

      Description
      NM_001369813.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3B7I2.1 GenPept UniProtKB/Swiss-Prot:Q3B7I2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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