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    Nup153 nucleoporin 153 [ Mus musculus (house mouse) ]

    Gene ID: 218210, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Nup153provided by MGI
    Official Full Name
    nucleoporin 153provided by MGI
    Primary source
    MGI:MGI:2385621
    See related
    Ensembl:ENSMUSG00000021374 AllianceGenome:MGI:2385621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B130015D15Rik
    Summary
    Predicted to enable several functions, including molecular condensate scaffold activity; nuclear localization sequence binding activity; and small GTPase binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in several processes, including amyloid fibril formation; negative regulation of RNA export from nucleus; and nucleocytoplasmic transport. Predicted to be located in annulate lamellae; cytosol; and nucleus. Predicted to be part of nuclear pore nuclear basket. Is expressed in cerebral cortex; embryo; lung; neural tube; and retina. Orthologous to human NUP153 (nucleoporin 153). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 42.1), thymus adult (RPKM 15.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nup153 in Genome Data Viewer
    Location:
    13 A5; 13 24.3 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (46833369..46890682, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (46679902..46727849, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35110 Neighboring gene STARR-seq mESC enhancer starr_34413 Neighboring gene STARR-seq mESC enhancer starr_34414 Neighboring gene cyclase associated actin cytoskeleton regulatory protein 2 Neighboring gene VISTA enhancer mm132 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:46712127-46712352 Neighboring gene STARR-seq mESC enhancer starr_34416 Neighboring gene family with sequence similarity 8, member A1 Neighboring gene STARR-seq mESC enhancer starr_34420 Neighboring gene STARR-positive B cell enhancer ABC_E9876 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:46831628-46831815 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:46831840-46832060 Neighboring gene predicted gene, 46412 Neighboring gene kinesin family member 13A Neighboring gene predicted gene, 24620 Neighboring gene STARR-seq mESC enhancer starr_34424 Neighboring gene predicted gene, 22960

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Jacinto FV, et al. Genes Dev, 2015 Jun 15. PMID 26080816, Free PMC Article
    2. Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD. Colussi C, et al. Stem Cell Res Ther, 2024 Sep 3. PMID 39227892, Free PMC Article
    3. Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding. Kadota S, et al. Nat Commun, 2020 May 25. PMID 32451376, Free PMC Article
    4. Altered Nup153 Expression Impairs the Function of Cultured Hippocampal Neural Stem Cells Isolated from a Mouse Model of Alzheimer's Disease. Leone L, et al. Mol Neurobiol, 2019 Aug. PMID 30689197
    5. Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells. Toda T, et al. Cell Stem Cell, 2017 Nov 2. PMID 28919367

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD.
      Title: Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD.
    2. Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding.
      Title: Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding.
    3. These data uncover a novel role for Nup153 in neural stem cells from animal model of Alzheimer's disease.
      Title: Altered Nup153 Expression Impairs the Function of Cultured Hippocampal Neural Stem Cells Isolated from a Mouse Model of Alzheimer's Disease.
    4. Nucleoporins 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells.
      Title: Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells.
    5. Nup153 and Sox2 bind and co-regulate hundreds of genes.
      Title: Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.
    6. Nup50 dynamics are independent of importin alpha, Nup153, and Nup98, even though the latter two proteins also exhibit transcription-dependent mobility.
      Title: Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics.
    7. results demonstrate a chromatin-associated role of Nup153 in maintaining stem cell pluripotency by functioning in mammalian epigenetic gene silencing
      Title: The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of RNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in annulate lamellae ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear inclusion body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasmic side of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear pore complex protein Nup153

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175749.2 → NP_786925.2  nuclear pore complex protein Nup153

      Status: VALIDATED

      Source sequence(s)
      AK031006, AK044947, AK086847, BM950067, CA326562, CF897724, CF898039, CK638380
      Consensus CDS
      CCDS26486.1
      UniProtKB/TrEMBL
      E9Q3G8, Q80WR0
      Related
      ENSMUSP00000021803.9, ENSMUST00000021803.10
      Conserved Domains (4) summary
      sd00025
      Location:658 → 677
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:718 → 746
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam08604
      Location:114 → 625
      Nup153; Nucleoporin Nup153-like
      pfam10599
      Location:1372 → 1462
      Nup_retrotrp_bd; Retro-transposon transporting motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      46833369..46890682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157992.1 → XP_036013885.1  nuclear pore complex protein Nup153 isoform X1

      UniProtKB/TrEMBL
      Q80WR0
      Conserved Domains (4) summary
      sd00025
      Location:367 → 386
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam10599
      Location:1081 → 1171
      Nup_retrotrp_bd; Retro-transposon transporting motif
      pfam00641
      Location:427 → 455
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam08604
      Location:1 → 326
      Nup153; Nucleoporin Nup153-like

    2. XM_036157993.1 → XP_036013886.1  nuclear pore complex protein Nup153 isoform X2

      UniProtKB/TrEMBL
      Q80UN3
      Conserved Domains (4) summary
      sd00025
      Location:147 → 166
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam10599
      Location:861 → 951
      Nup_retrotrp_bd; Retro-transposon transporting motif
      pfam00641
      Location:207 → 235
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam08604
      Location:1 → 106
      Nup153; Nucleoporin Nup153-like
    Nucleotide Protein Strain
    Heading Accession and Version

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