Lacc1 laccase domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lacc1provided by MGI
Official Full Name: laccase domain containing 1provided by MGI
Primary source: MGI:MGI:2445077
See related: Ensembl:ENSMUSG00000044350 AllianceGenome:MGI:2445077
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9030625A04Rik
Summary: Predicted to enable adenosine deaminase activity; copper ion binding activity; and pentosyltransferase activity. Involved in regulation of inflammatory response and regulation of purine nucleotide metabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in juvenile rheumatoid arthritis. Orthologous to human LACC1 (laccase domain containing 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 5.9), liver E18 (RPKM 5.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 40.63 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (77261640..77274344, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (77021739..77036929, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive Disorder Model via RIP2 Expression through ROS-NOD2 Induction.
Title: LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive Disorder Model via RIP2 Expression through ROS-NOD2 Induction.
LACC1 regulates changes in the intestinal flora in a mouse model of inflammatory bowel disease.
Title: LACC1 regulates changes in the intestinal flora in a mouse model of inflammatory bowel disease.
LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages.
Title: LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages.
Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation.
Title: Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation.
this study shows that LACC1 regulates TNF and IL-17 in mouse models of arthritis and inflammation
Title: LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation.
this study shows that Lacc1 is a central regulator of the metabolic function and bioenergetic state of macrophages that is under evolutionary selection and determines the risk of inflammatory and infectious disease
Title: C13orf31 (FAMIN) is a central regulator of immunometabolic function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491807

34.MMHAP97FRD10.seq (e-PCR)
- UniSTS:124123

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2'-deoxyadenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables S-methyl-5-thioadenosine phosphorylase activity	ISO Inferred from Sequence Orthology more info
enables S-methyl-5-thioadenosine phosphorylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables adenosine deaminase activity	ISO Inferred from Sequence Orthology more info
enables adenosine deaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables guanosine phosphorylase activity	ISO Inferred from Sequence Orthology more info
enables guanosine phosphorylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
NOT enables oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	ISS Inferred from Sequence or Structural Similarity more info
enables purine-nucleoside phosphorylase activity	ISO Inferred from Sequence Orthology more info
enables purine-nucleoside phosphorylase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in pattern recognition receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokine production involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular pH	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of purine nucleotide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: purine nucleoside phosphorylase LACC1

Names: S-methyl-5'-thioadenosine phosphorylase LACC1; adenosine deaminase LACC1; fatty acid metabolism-immunity nexus; guanosine phosphorylase LACC1; laccase (multicopper oxidoreductase) domain containing 1; laccase domain-containing protein 1

NP_766076.1

EC 2.4.2.1

EC 2.4.2.28

EC 3.5.4.4

XP_030103569.1

EC 2.4.2.1

EC 2.4.2.28

EC 3.5.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172488.2 → NP_766076.1 purine nucleoside phosphorylase LACC1

See identical proteins and their annotated locations for NP_766076.1

Status: PROVISIONAL

Source sequence(s)

AK033565

Consensus CDS

CCDS27287.1

UniProtKB/Swiss-Prot

Q14AQ3, Q3U600, Q8BZT9

Related

ENSMUSP00000059173.9, ENSMUST00000062789.15

Conserved Domains (1) summary

pfam02578
Location:218 → 426

Cu-oxidase_4; Multi-copper polyphenol oxidoreductase laccase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

77261640..77274344 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247709.2 → XP_030103569.1 purine nucleoside phosphorylase LACC1 isoform X1

Conserved Domains (1) summary

pfam02578
Location:5 → 170

Cu-oxidase_4; Multi-copper polyphenol oxidoreductase laccase