Lyl1 lymphoblastomic leukemia 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lyl1provided by MGI
Official Full Name: lymphoblastomic leukemia 1provided by MGI
Primary source: MGI:MGI:96891
See related: Ensembl:ENSMUSG00000034041 AllianceGenome:MGI:96891
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lyl-1; bHLHa18
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in B cell differentiation and definitive hemopoiesis. Predicted to be located in nucleus. Is expressed in central nervous system; genitourinary system; heart; liver; and thymus primordium. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human LYL1 (LYL1 basic helix-loop-helix family member). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in spleen adult (RPKM 50.2), liver E14.5 (RPKM 33.8) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 41.02 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (85428051..85432876)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84701423..84704716)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response to Mycobacterium tuberculosis infection in mice.
Title: Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response to Mycobacterium tuberculosis infection in mice.
Lyl-1 regulates primitive macrophages and microglia development.
Title: Lyl-1 regulates primitive macrophages and microglia development.
In Lyl1(-/-) mice, adipose stem cell vascular niche impairment leads to premature development of fat tissues.
Title: In Lyl1(-/-) mice, adipose stem cell vascular niche impairment leads to premature development of fat tissues.
Scl and Lyl1 share functional roles in platelet production by regulating expression of partner proteins including Gata1. This functional redundancy provides one explanation for the absence of Scl and Lyl1 mutations in inherited thrombocytopenia.
Title: Shared roles for Scl and Lyl1 in murine platelet production and function.
NHD13 transgenic mice lacking Lyl1 showed accelerated T-ALL and absence of transformation to AML, associated with a loss of multipotent progenitors in the bone marrow. Thus multiple T cell oncogenes induce thymocyte self-renewal via Lmo2/Lyl1.
Title: The NUP98-HOXD13 fusion oncogene induces thymocyte self-renewal via Lmo2/Lyl1.
Lyl1 can maintain primitive erythropoiesis.
Title: A novel role for Lyl1 in primitive erythropoiesis.
Loss of Lyl1 is associated with lung endothelial barrier disruption.
Title: Lung endothelial barrier disruption in Lyl1-deficient mice.
Lyl1 is critical for all oncogenic functions of Lmo2, including upregulation of a stem cell-like gene signature, aberrant self-renewal of thymocytes, and subsequent generation of T-cell leukemia.
Title: Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL.
Lyl-1 is a pivotal component of a transcriptional program that controls the lymphoid specification and maintenance of early T lineage progenitors
Title: The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors.
results suggest that LYL-1 plays a definite role in erythropoiesis, albeit with different effects in bone marrow specifically regulating basal erythropoiesis, and spleen, controlling stress-induced erythropoiesis
Title: LYL-1 deficiency induces a stress erythropoiesis.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel maturation	ISO Inferred from Sequence Orthology more info
involved_in blood vessel maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein lyl-1

Names: lymphoblastic leukemia-derived sequence 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008535.2 → NP_032561.2 protein lyl-1

See identical proteins and their annotated locations for NP_032561.2

Status: VALIDATED

Source sequence(s)

AC145556, AK076114, BY235816, CO044699

Consensus CDS

CCDS22476.1

UniProtKB/Swiss-Prot

P27792, Q4FK84, Q8BPE2, Q923F0

Related

ENSMUSP00000046010.5, ENSMUST00000037165.6

Conserved Domains (1) summary

cd19705
Location:145 → 209

bHLH_TS_LYL1; basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

85428051..85432876

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530744.4 → XP_006530807.1 protein lyl-1 isoform X1

See identical proteins and their annotated locations for XP_006530807.1

UniProtKB/Swiss-Prot

P27792, Q4FK84, Q8BPE2, Q923F0

Conserved Domains (1) summary

cd19705
Location:145 → 209

bHLH_TS_LYL1; basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins
XM_006530745.4 → XP_006530808.1 protein lyl-1 isoform X2

UniProtKB/TrEMBL

A0A571BE88

Related

ENSMUSP00000158636.2, ENSMUST00000238562.2

Conserved Domains (1) summary

cl00081
Location:72 → 136

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily