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    Pinlyp phospholipase A2 inhibitor and LY6/PLAUR domain containing [ Mus musculus (house mouse) ]

    Gene ID: 641361, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Pinlypprovided by MGI
    Official Full Name
    phospholipase A2 inhibitor and LY6/PLAUR domain containingprovided by MGI
    Primary source
    MGI:MGI:3615324
    See related
    Ensembl:ENSMUSG00000011632 AllianceGenome:MGI:3615324
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310033E01Rik
    Summary
    Predicted to enable phospholipase inhibitor activity. Predicted to be located in extracellular region. Orthologous to human PINLYP (phospholipase A2 inhibitor and LY6/PLAUR domain containing). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in stomach adult (RPKM 15.5), testis adult (RPKM 6.0) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pinlyp in Genome Data Viewer
    Location:
    7 A3; 7 11.38 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24241079..24246045, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24541654..24546668, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 428 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25315449-25315632 Neighboring gene immunity-related GTPase family, Q Neighboring gene STARR-seq mESC enhancer starr_18269 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 1 Neighboring gene zinc finger protein 575 Neighboring gene ethylmalonic encephalopathy 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity. Liu Z, et al. Proc Natl Acad Sci U S A, 2022 Jan 4. PMID 34969857, Free PMC Article
    2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
    3. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity.
      Title: Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phospholipase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037143.3 → NP_001032220.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein precursor

      See identical proteins and their annotated locations for NP_001032220.1

      Status: VALIDATED

      Source sequence(s)
      AC161166
      Consensus CDS
      CCDS20954.1
      UniProtKB/Swiss-Prot
      Q9CQD7, Q9D6V5
      UniProtKB/TrEMBL
      B2RSX2
      Related
      ENSMUSP00000011776.7, ENSMUST00000011776.8
      Conserved Domains (1) summary
      cl10471
      Location:27 → 107
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24241079..24246045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540274.5 → XP_006540337.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_006540337.1

      UniProtKB/Swiss-Prot
      Q9CQD7, Q9D6V5
      UniProtKB/TrEMBL
      B2RSX2
      Conserved Domains (1) summary
      cl10471
      Location:27 → 107
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQD7.1 GenPept UniProtKB/Swiss-Prot:Q9CQD7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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