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    Tfg Trk-fused gene [ Mus musculus (house mouse) ]

    Gene ID: 21787, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tfgprovided by MGI
    Official Full Name
    Trk-fused geneprovided by MGI
    Primary source
    MGI:MGI:1338041
    See related
    Ensembl:ENSMUSG00000022757 AllianceGenome:MGI:1338041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum exit site. Is expressed in several structures, including branchial arch; limb; nasal process; and nervous system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 57. Orthologous to human TFG (trafficking from ER to golgi regulator). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 162.5), small intestine adult (RPKM 131.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tfg in Genome Data Viewer
    Location:
    16 C1.1; 16 34.22 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (56510692..56541801, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (56690329..56717467, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41064 Neighboring gene discs, large homolog-associated protein 5 pseudogene Neighboring gene ABI family member 3 binding protein Neighboring gene STARR-seq mESC enhancer starr_41065 Neighboring gene STARR-seq mESC enhancer starr_41066 Neighboring gene STARR-seq mESC enhancer starr_41067 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:56717659-56717768 Neighboring gene STARR-seq mESC enhancer starr_41068 Neighboring gene adhesion G protein-coupled receptor G7 Neighboring gene predicted gene 15693 Neighboring gene transmembrane protein 45a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TFG is required for autophagy flux and to prevent endoplasmic reticulum stress in CH12 B lymphoma cells. Steinmetz TD, et al. Autophagy, 2021 Sep. PMID 32910713, Free PMC Article
    2. Identification of TFG- and Autophagy-Regulated Proteins and Glycerophospholipids in B Cells. Steinmetz TD, et al. J Proteome Res, 2024 May 3. PMID 38649144, Free PMC Article
    3. Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity. Yamamotoya T, et al. Sci Rep, 2017 Oct 12. PMID 29026155, Free PMC Article
    4. Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure. Beetz C, et al. Proc Natl Acad Sci U S A, 2013 Mar 26. PMID 23479643, Free PMC Article
    5. Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases. Yamamotoya T, et al. Sci Rep, 2022 Feb 4. PMID 35121777, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of TFG- and Autophagy-Regulated Proteins and Glycerophospholipids in B Cells.
      Title: Identification of TFG- and Autophagy-Regulated Proteins and Glycerophospholipids in B Cells.
    2. TFG is required for autophagy flux and to prevent endoplasmic reticulum stress in CH12 B lymphoma cells.
      Title: TFG is required for autophagy flux and to prevent endoplasmic reticulum stress in CH12 B lymphoma cells.
    3. TFG in pancreatic beta-cells plays a vital role in maintaining both the mass and function of beta-cells, and its dysfunction increases the tendency to develop glucose intolerance.
      Title: Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.
    4. Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure.
      Title: Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein TFG

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252443.1 → NP_001239372.1  protein TFG isoform 2

      See identical proteins and their annotated locations for NP_001239372.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      CT025158
      UniProtKB/TrEMBL
      Q8C2C6, Q9D828
      Conserved Domains (1) summary
      cd06401
      Location:11 → 89
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...

    2. NM_001357124.1 → NP_001344053.1  protein TFG isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT025158
      Conserved Domains (1) summary
      cd06401
      Location:11 → 91
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...

    3. NM_001357125.1 → NP_001344054.1  protein TFG isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025158
      UniProtKB/TrEMBL
      Q9D828
      Conserved Domains (2) summary
      cd06401
      Location:11 → 91
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
      cl28271
      Location:291 → 393
      dnaA; chromosomal replication initiation protein; Provisional

    4. NM_001357126.1 → NP_001344055.1  protein TFG isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT025158
      Conserved Domains (1) summary
      cd06401
      Location:11 → 91
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...

    5. NM_019678.3 → NP_062652.1  protein TFG isoform 1

      See identical proteins and their annotated locations for NP_062652.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AK158539, BB783895, BB856666, BY061830
      Consensus CDS
      CCDS28224.1
      UniProtKB/TrEMBL
      Q9D828, Q9Z1A1
      Related
      ENSMUSP00000067867.8, ENSMUST00000065515.14
      Conserved Domains (2) summary
      cd06401
      Location:11 → 91
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
      PRK14086
      Location:295 → 397
      dnaA; chromosomal replication initiator protein DnaA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      56510692..56541801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521980.4 → XP_006522043.1  protein TFG isoform X1

      See identical proteins and their annotated locations for XP_006522043.1

      UniProtKB/TrEMBL
      Q9D828, Q9Z1A1
      Conserved Domains (2) summary
      cd06401
      Location:11 → 91
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
      PRK14086
      Location:295 → 397
      dnaA; chromosomal replication initiator protein DnaA
    Nucleotide Protein Strain
    Heading Accession and Version

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