Fgf16 fibroblast growth factor 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgf16provided by MGI
Official Full Name: fibroblast growth factor 16provided by MGI
Primary source: MGI:MGI:1931627
See related: Ensembl:ENSMUSG00000031230 AllianceGenome:MGI:1931627
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fgf4c
Summary: Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Predicted to be involved in several processes, including fibroblast growth factor receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of endothelial cell chemotaxis to fibroblast growth factor. Predicted to act upstream of or within positive regulation of brown fat cell proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including branchial arch; heart; inner ear; nose; and tongue. Human ortholog(s) of this gene implicated in syndactyly type 8. Orthologous to human FGF16 (fibroblast growth factor 16). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in heart adult (RPKM 1.9), frontal lobe adult (RPKM 0.4) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: X D; X 47.2 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (104808083..104820138)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (105764477..105776532)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mettl3-mediated m[6]A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration.
Title: Mettl3-mediated m(6)A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration.
Overexpression of Fgf16 in vivo recapitulated several of our in vitro findings, specifically the significant induction of the Ucp1 gene and UCP1 protein expression in inguinal white adipose tissue (iWAT)
Title: In Vitro and in Vivo Analyses Reveal Profound Effects of Fibroblast Growth Factor 16 as a Metabolic Regulator.
GATA4 is required for neonatal heart regeneration through regulation of Fgf16.
Title: GATA4 regulates Fgf16 to promote heart repair after injury.
results suggest a possible mechanism whereby Fgf16 prevents angiotensin II-induced cardiac hypertrophy and fibrosis by antagonizing Fgf2; the present findings should provide new insights into the roles of Fgf signaling in cardiac remodeling
Title: Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16.
Fgf-16 gene is a target for NF-kappaB activation in the postnatal heart.
Title: FGF-16 is a target for adrenergic stimulation through NF-kappaB activation in postnatal cardiac cells and adult mouse heart.
After three generations, 25% of Fgf-16(-/Y) mice survived to adulthood, which could be reversed by reducing the contribution of the C57BL/6 genetic background by back crossing to another strain.
Title: Embryonic survival and severity of cardiac and craniofacial defects are affected by genetic background in fibroblast growth factor-16 null mice.
Fgf16 does not have a unique role in inner ear development and the Fgf16 lineage is found throughout the three cristae, in portions of the semicircular canal ducts, and in the cochlear spiral prominence epithelial cells
Title: Fgf16(IRESCre) mice: a tool to inactivate genes expressed in inner ear cristae and spiral prominence epithelium.
proliferation of embryonic cardiomyocytes was significantly decreased, indicating that Fgf16 is a growth factor for these cells
Title: Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart.
These findings indicate FGF-16 is required for embryonic heart development in mid-gestation through its positive effect on myocardial growth.
Title: FGF-16 is required for embryonic heart development.
chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart
Title: A myocyte enhancer factor 2 (MEF2) site located in a hypersensitive region of the FGF16 gene locus is required for preferential promoter activity in neonatal cardiac myocytes.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

General gene information

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Markers

Fgf16 (e-PCR), detects polymorphism
- UniSTS:507918

Fgf16 (e-PCR), detects polymorphism
- UniSTS:516667

NoName (e-PCR)
- UniSTS:494220

Fgf16 (e-PCR), detects polymorphism
- UniSTS:532400

NoName (e-PCR)
- UniSTS:485301

Fgf16 (e-PCR), detects polymorphism
- UniSTS:258262

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of brown fat cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endothelial cell chemotaxis to fibroblast growth factor	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell chemotaxis to fibroblast growth factor	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor 16

Names: FGF-16; fibroblast growth factor 4c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.