U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dhodh dihydroorotate dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 56749, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dhodhprovided by MGI
    Official Full Name
    dihydroorotate dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:1928378
    See related
    Ensembl:ENSMUSG00000031730 AllianceGenome:MGI:1928378
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810417D19Rik
    Summary
    Enables dihydroorotase activity and dihydroorotate dehydrogenase activity. Involved in 'de novo' UMP biosynthetic process and UDP biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; branchial arch; limb bud; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 7.7), CNS E11.5 (RPKM 7.0) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dhodh in Genome Data Viewer
    Location:
    8 D3; 8 57.12 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110319876..110335330, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109593244..109608699, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39247 Neighboring gene haptoglobin Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112132543-112132726 Neighboring gene polycystic kidney disease 1 like 3 Neighboring gene increased sodium tolerance 1 homolog (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E3805 Neighboring gene zinc finger protein 821 Neighboring gene predicted gene, 53453

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Targeting DHODH reveals therapeutic opportunities in ATRA-resistant acute promyelocytic leukemia. Yang T, et al. Biomed Pharmacother, 2023 Oct. PMID 37579695
    2. On the role of dihydroorotate dehydrogenase in growth cessation of Ehrlich ascites tumor cells cultured under oxygen deficiency. Löffler M. Eur J Biochem, 1980. PMID 6249586
    3. Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Knecht W, et al. Chem Biol Interact, 2000 Jan 3. PMID 10658902
    4. In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine. Thomson TA, et al. Scand J Immunol, 2002 Jul. PMID 12100469
    5. 4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL-(Fas)lpr mice. Kulkarni OP, et al. Am J Pathol, 2010 Jun. PMID 20413687, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting DHODH reveals therapeutic opportunities in ATRA-resistant acute promyelocytic leukemia.
      Title: Targeting DHODH reveals therapeutic opportunities in ATRA-resistant acute promyelocytic leukemia.
    2. Knockdown of Dhodh reduced hippocampus mean firing rate.
      Title: Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility.
    3. DHODH inhibition led to a marked decrease in melanoma growth both in vitro and in mouse xenograft studies
      Title: DHODH modulates transcriptional elongation in the neural crest and melanoma.
    4. Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells of different species
      Title: Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells.
    5. immunosuppressive agent HR325 (an inhibitor of dihydroorotate dehydrogenase, DHODH) inhibits immunoglobulin (Ig) secretion both in vitro and in vivo and that this effect can be reverse with exogenous uridine
      Title: In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FMN binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dihydroorotase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables dihydroorotate dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydroorotate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydroorotate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables dihydroorotate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables quinone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquinone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' UMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' UMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UDP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyrimidine ribonucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    dihydroorotate dehydrogenase (quinone), mitochondrial
    Names
    DHOdehase
    dihydroorotate dehydrogenase, mitochondrial
    dihydroorotate oxidase
    NP_064430.1
    XP_036010093.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020046.3 → NP_064430.1  dihydroorotate dehydrogenase (quinone), mitochondrial precursor

      See identical proteins and their annotated locations for NP_064430.1

      Status: VALIDATED

      Source sequence(s)
      AC125162, BC045206
      Consensus CDS
      CCDS40471.1
      UniProtKB/Swiss-Prot
      O35435
      Related
      ENSMUSP00000115934.2, ENSMUST00000123605.9
      Conserved Domains (2) summary
      PLN02826
      Location:4 → 394
      PLN02826; dihydroorotate dehydrogenase
      cd04738
      Location:43 → 373
      DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      110319876..110335330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154200.1 → XP_036010093.1  dihydroorotate dehydrogenase (quinone), mitochondrial isoform X1

      Conserved Domains (1) summary
      cd04738
      Location:2 → 332
      DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

    RNA

    1. XR_387762.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35435.2 GenPept UniProtKB/Swiss-Prot:O35435

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous