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    PTENP1 phosphatase and tensin homolog pseudogene 1 [ Homo sapiens (human) ]

    Gene ID: 11191, updated on 17-Sep-2024

    Summary

    Official Symbol
    PTENP1provided by HGNC
    Official Full Name
    phosphatase and tensin homolog pseudogene 1provided by HGNC
    Primary source
    HGNC:HGNC:9589
    See related
    Ensembl:ENSG00000293199 MIM:613531; AllianceGenome:HGNC:9589
    Gene type
    pseudo
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTH2; PTEN2; PTEN-rs; PTENpg1; psiPTEN
    Summary
    PTENP1 represents a highly homologous processed pseudogene of PTEN (phosphatase and tensin homolog), a protein that encodes a tumor suppressor that functions by negatively regulating the AKT/PKB signaling pathway. PTENP1 is found on chromosome 9 and regulates PTEN by both sense and antisense RNAs (Gene ID: 101243555). This long-noncoding RNA (lncRNA) acts as a decoy for PTEN targeting microRNAs and also exerts a tumor suppressive activity. [provided by RefSeq, Jun 2020]
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    Genomic context

    See PTENP1 in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (33673504..33677420, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (33692015..33695931, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33673502..33677418, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene T cell receptor beta variable 24/OR9-2 (pseudogene) Neighboring gene Sharpr-MPRA regulatory region 1692 Neighboring gene Sharpr-MPRA regulatory region 11708 Neighboring gene MPRA-validated peak7219 silencer Neighboring gene T cell receptor beta variable 25/OR9-2 (pseudogene) Neighboring gene PTENP1 antisense RNA Neighboring gene T cell receptor beta variable A/OR9-2 (pseudogene) Neighboring gene T cell receptor beta variable 26/OR9-2 (pseudogene)

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Other Names

    • PTEN/MMAC1 pseudogene
    • phosphatase and tensin homolog (mutated in multiple advanced cancers 1), pseudogene 1
    • phosphatase and tensin homolog pseudogene 1 (functional)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_001337.2 

      Range
      67044..70960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. NR_023917.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL356489, BC038293, BY797336
      Related
      ENST00000532280.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      33673504..33677420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      33692015..33695931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)