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    EIF1AX eukaryotic translation initiation factor 1A X-linked [ Homo sapiens (human) ]

    Gene ID: 1964, updated on 9-Dec-2024

    Summary

    Official Symbol
    EIF1AXprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 1A X-linkedprovided by HGNC
    Primary source
    HGNC:HGNC:3250
    See related
    Ensembl:ENSG00000173674 MIM:300186; AllianceGenome:HGNC:3250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EIF1A; EIF4C; eIF-1A; eIF-4C; EIF1AP1
    Summary
    This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 20.5), endometrium (RPKM 20.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See EIF1AX in Genome Data Viewer
    Location:
    Xp22.12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (20124525..20141838, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (19707417..19724730, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (20142643..20159956, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene BCLAF1 and THRAP3 family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20695 Neighboring gene uncharacterized LOC729609 Neighboring gene MAP7 domain containing 2 Neighboring gene microRNA 23c Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29478 Neighboring gene EIF1AX antisense RNA 1 Neighboring gene small Cajal body-specific RNA 9 like Neighboring gene ribosomal protein S6 kinase A3 Neighboring gene Sharpr-MPRA regulatory region 15471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20697 Neighboring gene Sharpr-MPRA regulatory region 100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29484 Neighboring gene RN7SK pseudogene 183

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation factor activity, RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in ribosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of eukaryotic 43S preinitiation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of eukaryotic 43S preinitiation complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of eukaryotic 48S preinitiation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of multi-eIF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 1A, X-chromosomal
    Names
    Putative eukaryotic translation initiation factor 1A
    eIF1A X isoform
    eukaryotic translation initiation factor 1A, X chromosome
    eukaryotic translation initiation factor 4C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412.4NP_001403.1  eukaryotic translation initiation factor 1A, X-chromosomal

      See identical proteins and their annotated locations for NP_001403.1

      Status: REVIEWED

      Source sequence(s)
      AL732366, L18960
      Consensus CDS
      CCDS14196.1
      UniProtKB/Swiss-Prot
      B2R5U5, P47813, Q0VGC2, Q5JPS5, Q5JPS6
      Related
      ENSP00000368927.5, ENST00000379607.10
      Conserved Domains (1) summary
      PTZ00329
      Location:1131
      PTZ00329; eukaryotic translation initiation factor 1A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      20124525..20141838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      19707417..19724730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)