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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_029409.1 RefSeqGene
- Range
-
6600..65617
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001270485.2 → NP_001257414.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform 1
See identical proteins and their annotated locations for NP_001257414.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1, and encodes isoform (1). Variants 1 and 8 encode the same protein (isoform 1).
- Source sequence(s)
-
AA678930, AB081336, AF287630, AL834322, BC026060, DA075361
- Consensus CDS
-
CCDS9216.1
- UniProtKB/Swiss-Prot
- A8K7Q7, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q96RR4, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2
- UniProtKB/TrEMBL
-
B4DV02
- Related
- ENSP00000384600.3, ENST00000404169.8
- Conserved Domains (1) summary
-
- cd14199
Location:162 → 447
- STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2
-
NM_001270486.1 → NP_001257415.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform 7
See identical proteins and their annotated locations for NP_001257415.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (9) lacks a segment in the 3' coding region and 3' UTR, which leads to a frameshift, compared to variant 1. The resulting isoform (7) contains a shorter and distinct C-terminus compared to isoform 1.
- Source sequence(s)
-
AA678930, AB018330, AF321385, AL834322
- Consensus CDS
-
CCDS58283.1
- UniProtKB/TrEMBL
-
B4DV02
- Related
- ENSP00000376266.2, ENST00000392474.6
- Conserved Domains (2) summary
-
- smart00220
Location:165 → 446
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14199
Location:162 → 447
- STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2
-
NM_006549.4 → NP_006540.3 calcium/calmodulin-dependent protein kinase kinase 2 isoform 1
See identical proteins and their annotated locations for NP_006540.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (1), also known as beta 1, represents the longest transcript, and encodes the longest isoform (1). Variants 1 and 8 encode the same protein (isoform 1).
- Source sequence(s)
-
AC069209
- Consensus CDS
-
CCDS9216.1
- UniProtKB/Swiss-Prot
- A8K7Q7, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q96RR4, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2
- UniProtKB/TrEMBL
-
B4DV02
- Related
- ENSP00000312741.5, ENST00000324774.9
- Conserved Domains (1) summary
-
- cd14199
Location:162 → 447
- STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2
-
NM_153499.3 → NP_705719.2 calcium/calmodulin-dependent protein kinase kinase 2 isoform 2
See identical proteins and their annotated locations for NP_705719.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2), also known as beta 1del16, lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus compared to isoform 1. This isoform (2) is also encoded by variant 7.
- Source sequence(s)
-
AC069209
- Consensus CDS
-
CCDS9218.1
- UniProtKB/TrEMBL
-
B4DV02
- Related
- ENSP00000336634.3, ENST00000337174.7
- Conserved Domains (1) summary
-
- cd14199
Location:162 → 447
- STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2
-
NM_153500.2 → NP_705720.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform 4
See identical proteins and their annotated locations for NP_705720.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4), also known as beta 1del14del16, has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting isoform (4) has a distinct C-terminus and is shorter than isoform 1.
- Source sequence(s)
-
AC069209
- Consensus CDS
-
CCDS9219.1
- UniProtKB/TrEMBL
-
B4DV02
- Related
- ENSP00000445944.1, ENST00000538733.5
- Conserved Domains (1) summary
-
- cl21453
Location:162 → 442
- PKc_like; Protein Kinases, catalytic domain
-
NM_172214.3 → NP_757363.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform 5
See identical proteins and their annotated locations for NP_757363.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5), also known as beta 2, contains an alternate segment in the 3' coding region and differs in the 3' UTR, compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
AC069209, AF287631
- Consensus CDS
-
CCDS44999.1
- UniProtKB/TrEMBL
-
B4DV02
- Related
- ENSP00000376265.2, ENST00000392473.2
- Conserved Domains (1) summary
-
- cd14199
Location:162 → 447
- STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2
-
NM_172215.3 → NP_757364.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform 6
See identical proteins and their annotated locations for NP_757364.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (6), also known as beta 2del14, differs in the 3' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (6) with a distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
AC069209, AF287631
- Consensus CDS
-
CCDS53837.1
- UniProtKB/TrEMBL
-
B4DV02
- Related
- ENSP00000388273.2, ENST00000446440.6
- Conserved Domains (1) summary
-
- cl21453
Location:162 → 442
- PKc_like; Protein Kinases, catalytic domain
-
NM_172216.2 → NP_757365.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform 3
See identical proteins and their annotated locations for NP_757365.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3), also known as beta 1del14, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), that is missing an internal segment compared to isoform 1.
- Source sequence(s)
-
AC069209
- Consensus CDS
-
CCDS9217.1
- UniProtKB/TrEMBL
-
B4DV02
- Related
- ENSP00000321230.3, ENST00000347034.6
- Conserved Domains (1) summary
-
- cl21453
Location:162 → 442
- PKc_like; Protein Kinases, catalytic domain
-
NM_172226.3 → NP_757380.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform 2
See identical proteins and their annotated locations for NP_757380.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) differs in the 5' UTR and also lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus compared to isoform 1. This isoform (2) is also encoded by variant 2.
- Source sequence(s)
-
AB018330, AC069209, AI612762, BC026060, DA075361
- Consensus CDS
-
CCDS9218.1
- UniProtKB/TrEMBL
-
B4DV02
- Related
- ENSP00000388368.2, ENST00000412367.6
- Conserved Domains (1) summary
-
- cd14199
Location:162 → 447
- STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000012.12 Reference GRCh38.p14 Primary Assembly
- Range
-
121237692..121297819 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_017018702.3 → XP_016874191.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X2
- UniProtKB/TrEMBL
-
B4DV02
- Conserved Domains (2) summary
-
- smart00220
Location:165 → 446
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14199
Location:162 → 447
- STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2
-
XM_005253824.3 → XP_005253881.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X8
See identical proteins and their annotated locations for XP_005253881.1
- UniProtKB/TrEMBL
-
B4DV02
- Conserved Domains (1) summary
-
- cl21453
Location:162 → 442
- PKc_like; Protein Kinases, catalytic domain
-
XM_047428105.1 → XP_047284061.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X6
- UniProtKB/TrEMBL
-
B4DV02
-
XM_005253822.3 → XP_005253879.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X3
See identical proteins and their annotated locations for XP_005253879.1
- UniProtKB/TrEMBL
-
B4DV02
- Conserved Domains (1) summary
-
- cl21453
Location:162 → 442
- PKc_like; Protein Kinases, catalytic domain
-
XM_011537763.1 → XP_011536065.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X2
See identical proteins and their annotated locations for XP_011536065.1
- UniProtKB/TrEMBL
-
B4DV02
- Conserved Domains (2) summary
-
- smart00220
Location:165 → 446
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14199
Location:162 → 447
- STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2
-
XM_047428107.1 → XP_047284063.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X8
- UniProtKB/TrEMBL
-
B4DV02
-
XM_047428103.1 → XP_047284059.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X4
- UniProtKB/TrEMBL
-
B4DV02
-
XM_047428102.1 → XP_047284058.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X2
- UniProtKB/TrEMBL
-
B4DV02
-
XM_047428101.1 → XP_047284057.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X1
- UniProtKB/Swiss-Prot
- A8K7Q7, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q96RR4, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2
- UniProtKB/TrEMBL
-
B4DV02
-
XM_011537764.3 → XP_011536066.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X10
- Conserved Domains (2) summary
-
- smart00220
Location:9 → 282
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cl21453
Location:9 → 283
- PKc_like; Protein Kinases, catalytic domain
-
XM_047428109.1 → XP_047284065.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X11
-
XM_047428108.1 → XP_047284064.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X9
- UniProtKB/TrEMBL
-
B4DV02
-
XM_005253823.1 → XP_005253880.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X5
See identical proteins and their annotated locations for XP_005253880.1
- UniProtKB/TrEMBL
-
B4DV02
- Conserved Domains (1) summary
-
- cd14199
Location:162 → 447
- STKc_CaMKK2; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2
-
XM_047428104.1 → XP_047284060.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X5
- UniProtKB/TrEMBL
-
B4DV02
-
XM_047428106.1 → XP_047284062.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X7
- UniProtKB/TrEMBL
-
B4DV02
Alternate T2T-CHM13v2.0
Genomic
-
NC_060936.1 Alternate T2T-CHM13v2.0
- Range
-
121228458..121289212 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054370799.1 → XP_054226774.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X2
- UniProtKB/TrEMBL
-
B4DV02
-
XM_054370806.1 → XP_054226781.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X8
- UniProtKB/TrEMBL
-
B4DV02
-
XM_054370804.1 → XP_054226779.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X6
- UniProtKB/TrEMBL
-
B4DV02
-
XM_054370800.1 → XP_054226775.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X3
- UniProtKB/TrEMBL
-
B4DV02
-
XM_054370797.1 → XP_054226772.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X2
- UniProtKB/TrEMBL
-
B4DV02
-
XM_054370807.1 → XP_054226782.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X8
- UniProtKB/TrEMBL
-
B4DV02
-
XM_054370801.1 → XP_054226776.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X4
- UniProtKB/TrEMBL
-
B4DV02
-
XM_054370798.1 → XP_054226773.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X2
- UniProtKB/TrEMBL
-
B4DV02
-
XM_054370796.1 → XP_054226771.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X1
- UniProtKB/Swiss-Prot
- A8K7Q7, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q96RR4, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2
- UniProtKB/TrEMBL
-
B4DV02
-
XM_054370809.1 → XP_054226784.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X10
-
XM_054370810.1 → XP_054226785.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X11
-
XM_054370808.1 → XP_054226783.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X9
- UniProtKB/TrEMBL
-
B4DV02
-
XM_054370802.1 → XP_054226777.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X5
- UniProtKB/TrEMBL
-
B4DV02
-
XM_054370803.1 → XP_054226778.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X5
- UniProtKB/TrEMBL
-
B4DV02
-
XM_054370805.1 → XP_054226780.1 calcium/calmodulin-dependent protein kinase kinase 2 isoform X7
- UniProtKB/TrEMBL
-
B4DV02