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    FRY FRY microtubule binding protein [ Homo sapiens (human) ]

    Gene ID: 10129, updated on 3-Dec-2024

    Summary

    Official Symbol
    FRYprovided by HGNC
    Official Full Name
    FRY microtubule binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:20367
    See related
    Ensembl:ENSG00000073910 MIM:614818; AllianceGenome:HGNC:20367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CG003; 13CDNA73; 214K23.2; C13orf14; bA207N4.2; bA37E23.1
    Summary
    Predicted to enable enzyme inhibitor activity. Predicted to be involved in cell morphogenesis and neuron projection development. Predicted to be located in centrosome; cytoplasm; and spindle pole. Predicted to be active in cell cortex and site of polarized growth. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart (RPKM 6.3), brain (RPKM 4.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FRY in Genome Data Viewer
    Location:
    13q13.1
    Exon count:
    64
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (32031774..32299125)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (31248643..31516370)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (32605911..32873262)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900336 Neighboring gene uncharacterized LOC124903149 Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:32519515-32520016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:32520017-32520516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7553 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5244 Neighboring gene Sharpr-MPRA regulatory region 10155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5245 Neighboring gene FRY antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 2624 Neighboring gene NANOG hESC enhancer GRCh37_chr13:32716946-32717447 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:32739396-32740595 Neighboring gene Sharpr-MPRA regulatory region 7321 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:32784277-32785476 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:32827763-32828962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5246 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5247 Neighboring gene BRCA2 promoter/silencer region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7554 Neighboring gene zygote arrest 1 like Neighboring gene BRCA2 DNA repair associated Neighboring gene Sharpr-MPRA regulatory region 1962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7555 Neighboring gene interferon induced protein with tetratricopeptide repeats 1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog
    Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of tubulin deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein furry homolog
    Names
    WUGSC:H_2G3A.1
    furry homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411012.1NP_001397941.1  protein furry homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL137143, AL138692, AL445212
      Consensus CDS
      CCDS91795.1
      UniProtKB/TrEMBL
      A0A286YFA9, A0A2R8YCY2
      Related
      ENSP00000493189.1, ENST00000642040.1
    2. NM_023037.3NP_075463.2  protein furry homolog isoform 1

      See identical proteins and their annotated locations for NP_075463.2

      Status: VALIDATED

      Source sequence(s)
      AA993094, AL049784, AL445212, U50534
      Consensus CDS
      CCDS41875.1
      UniProtKB/Swiss-Prot
      Q5TBA9, Q9Y3N6
      UniProtKB/TrEMBL
      A0A2R8YCY2
      Related
      ENSP00000445043.2, ENST00000542859.6
      Conserved Domains (3) summary
      pfam14222
      Location:165672
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:20422295
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:11411513
      MOR2-PAG1_mid; Cell morphogenesis central region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      32031774..32299125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429999.1XP_047285955.1  protein furry homolog isoform X1

      UniProtKB/TrEMBL
      A0A2R8YCY2
    2. XM_047430000.1XP_047285956.1  protein furry homolog isoform X2

      UniProtKB/TrEMBL
      A0A2R8YCY2
    3. XM_006719749.4XP_006719812.1  protein furry homolog isoform X3

      UniProtKB/TrEMBL
      A0A2R8YCY2
      Conserved Domains (3) summary
      pfam14222
      Location:162669
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:20392292
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:11381510
      MOR2-PAG1_mid; Cell morphogenesis central region
    4. XM_017020306.2XP_016875795.1  protein furry homolog isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      31248643..31516370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373973.1XP_054229948.1  protein furry homolog isoform X1

      UniProtKB/TrEMBL
      A0A2R8YCY2
    2. XM_054373974.1XP_054229949.1  protein furry homolog isoform X2

      UniProtKB/TrEMBL
      A0A2R8YCY2
    3. XM_054373975.1XP_054229950.1  protein furry homolog isoform X3

      UniProtKB/TrEMBL
      A0A2R8YCY2
    4. XM_054373976.1XP_054229951.1  protein furry homolog isoform X4