FKBP3 FKBP prolyl isomerase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FKBP3provided by HGNC
Official Full Name: FKBP prolyl isomerase 3provided by HGNC
Primary source: HGNC:HGNC:3719
See related: Ensembl:ENSG00000100442 MIM:186947; AllianceGenome:HGNC:3719
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FKBP-3; FKBP25; PPIase; FKBP-25
Summary: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]
Expression: Ubiquitous expression in brain (RPKM 15.6), prostate (RPKM 14.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q21.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (45115599..45134481, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (39307610..39327326, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (45584802..45603684, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FKBP3, a poor prognostic indicator, promotes the progression of LUAD via regulating ferroptosis and immune infiltration.
Title: FKBP3, a poor prognostic indicator, promotes the progression of LUAD via regulating ferroptosis and immune infiltration.
Knockdown of FKBP3 suppresses nasopharyngeal carcinoma cell growth, invasion and migration, deactivated NF-kappaB/IL-6 signaling pathway through inhibiting histone deacetylase 2 expression.
Title: Knockdown of FKBP3 suppresses nasopharyngeal carcinoma cell growth, invasion and migration, deactivated NF-κB/IL-6 signaling pathway through inhibiting histone deacetylase 2 expression.
Esterase D stabilizes FKBP25 to suppress mTORC1.
Title: Esterase D stabilizes FKBP25 to suppress mTORC1.
FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat.
Title: FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat.
The results identify FKBP25 as a component of the DNA double-strand breaks (DSB) repair pathway.
Title: FKBP25 participates in DNA double-strand break repair.
Results demonstrate that FKBP25 is a novel microtubule-associated protein that engages both nucleic acids and microtubules, and that these interactions are controlled by carefully timed phosphorylation events to ensure proper cell division and genome segregation.
Title: The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability.
Taken together, these data clearly show that FKBP3/Sp1/HDAC2/p27 control cell proliferation during non-small cell lung cancer development.
Title: FKBP3 Promotes Proliferation of Non-Small Cell Lung Cancer Cells through Regulating Sp1/HDAC2/p27.
Data show that the N-terminus of FK506 binding protein-25 (FKBP25) is anchored to regions of dsRNA, whereas the FKBP domain is free to interact with neighboring proteins.
Title: The basic tilted helix bundle domain of the prolyl isomerase FKBP25 is a novel double-stranded RNA binding module.
Structural basis for nucleic acid recognition by FKBP25 has been uncovered.
Title: Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin.
proteomics study indicates that the nuclear pool of the FKBP25 targets various nuclear proteins that are crucial for packaging of DNA, chromatin remodeling and pre-mRNA splicing
Title: Rapamycin-binding FKBP25 associates with diverse proteins that form large intracellular entities.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH91677 (e-PCR)
- UniSTS:88861

G36144 (e-PCR)
- UniSTS:64923

G64679 (e-PCR)
- UniSTS:163792

SHGC-31929 (e-PCR)
- UniSTS:6870

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables FK506 binding	TAS Traceable Author Statement more info	PubMed
enables RNA binding	HDA more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase FKBP3

Names: 25 kDa FK506-binding protein; 25 kDa FKBP; FK506 binding protein 3, 25kDa; FK506-binding protein 25, T-cell; FK506-binding protein 3; PPIase FKBP3; immunophilin FKBP25; rapamycin binding protein; rapamycin-selective 25 kDa immunophilin; rotamase

NP_002004.1

EC 5.2.1.8

XP_011534867.1

EC 5.2.1.8

XP_054231554.1

EC 5.2.1.8

XP_054231555.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002013.4 → NP_002004.1 peptidyl-prolyl cis-trans isomerase FKBP3

See identical proteins and their annotated locations for NP_002004.1

Status: REVIEWED

Source sequence(s)

BC020809, BI598048, CN315192

Consensus CDS

CCDS9683.1

UniProtKB/Swiss-Prot

B2R4Q9, Q00688, Q14317

UniProtKB/TrEMBL

Q53GD8

Related

ENSP00000379374.3, ENST00000396062.4

Conserved Domains (2) summary

pfam00254
Location:124 → 221

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

pfam18410
Location:6 → 77

BTHB; Basic tilted helix bundle domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

45115599..45134481 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011536565.4 → XP_011534867.1 peptidyl-prolyl cis-trans isomerase FKBP3 isoform X1

UniProtKB/TrEMBL

Q53GD8

Conserved Domains (1) summary

pfam00254
Location:91 → 188

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

Alternate T2T-CHM13v2.0

Genomic

NC_060938.1 Alternate T2T-CHM13v2.0

Range

39307610..39327326 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054375579.1 → XP_054231554.1 peptidyl-prolyl cis-trans isomerase FKBP3 isoform X2

UniProtKB/Swiss-Prot

B2R4Q9, Q00688, Q14317
XM_054375580.1 → XP_054231555.1 peptidyl-prolyl cis-trans isomerase FKBP3 isoform X1