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    NPR1 natriuretic peptide receptor 1 [ Homo sapiens (human) ]

    Gene ID: 4881, updated on 9-Dec-2024

    Summary

    Official Symbol
    NPR1provided by HGNC
    Official Full Name
    natriuretic peptide receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:7943
    See related
    Ensembl:ENSG00000169418 MIM:108960; AllianceGenome:HGNC:7943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANPa; NPRA; ANPRA; GUC2A; GUCY2A
    Summary
    Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]
    Expression
    Biased expression in fat (RPKM 49.0), lung (RPKM 10.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NPR1 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153678688..153693992)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152815953..152831256)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153651164..153666468)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SNAP associated protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1754 Neighboring gene tRNA-iMet (anticodon CAT) 1-1 Neighboring gene interleukin enhancer binding factor 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153650401-153651382 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153651383-153652363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153656981-153657482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153657483-153657982 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:153659386-153660585 Neighboring gene microRNA 8083 Neighboring gene gem nuclear organelle associated protein 2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 372, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:153700292-153700463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153706223-153706722 Neighboring gene integrator complex subunit 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:153717251-153717990 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153717991-153718730 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled peptide receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hormone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables natriuretic peptide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide hormone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood vessel diameter maintenance NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in body fluid secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cGMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cGMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cGMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of renal sodium excretion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of urine volume TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor guanylyl cyclase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor guanylyl cyclase signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of blood pressure NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of vascular permeability TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of ANPR-A receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    atrial natriuretic peptide receptor 1
    Names
    ANP-A
    ANPR-A
    GC-A
    NPR-A
    atrial natriuretic peptide receptor type A
    atrionatriuretic peptide receptor A
    guanylate cyclase A
    natriuretic peptide A type receptor
    natriuretic peptide receptor A
    natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
    testicular tissue protein Li 20
    NP_000897.3
    XP_005245275.1
    XP_016856863.1
    XP_054192771.1
    XP_054192772.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000906.4NP_000897.3  atrial natriuretic peptide receptor 1 precursor

      See identical proteins and their annotated locations for NP_000897.3

      Status: VALIDATED

      Source sequence(s)
      AK025024
      Consensus CDS
      CCDS1051.1
      UniProtKB/Swiss-Prot
      B0ZBF0, P16066, Q5SR08, Q6P4Q3
      UniProtKB/TrEMBL
      A0A140VJE6
      Related
      ENSP00000357669.3, ENST00000368680.4
      Conserved Domains (7) summary
      cd06385
      Location:36443
      PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor
      smart00219
      Location:547801
      TyrKc; Tyrosine kinase, catalytic domain
      smart00044
      Location:8401032
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:534807
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:8671053
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:54414
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:816861
      HNOBA; Heme NO binding associated

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      153678688..153693992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245218.3XP_005245275.1  atrial natriuretic peptide receptor 1 isoform X1

      Conserved Domains (6) summary
      cd06385
      Location:36443
      PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor
      smart00044
      Location:8141006
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:534781
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:8411027
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:54414
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:790835
      HNOBA; Heme NO binding associated
    2. XM_017001374.3XP_016856863.1  atrial natriuretic peptide receptor 1 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      152815953..152831256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336796.1XP_054192771.1  atrial natriuretic peptide receptor 1 isoform X1

    2. XM_054336797.1XP_054192772.1  atrial natriuretic peptide receptor 1 isoform X2