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    EXOSC4 exosome component 4 [ Homo sapiens (human) ]

    Gene ID: 54512, updated on 9-Dec-2024

    Summary

    Official Symbol
    EXOSC4provided by HGNC
    Official Full Name
    exosome component 4provided by HGNC
    Primary source
    HGNC:HGNC:18189
    See related
    Ensembl:ENSG00000178896 MIM:606491; AllianceGenome:HGNC:18189
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SKI6; p12A; RRP41; Ski6p; RRP41A; Rrp41p; hRrp41p
    Summary
    Enables mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including DNA deamination; maturation of 5.8S rRNA; and nuclear-transcribed mRNA catabolic process. Acts upstream of or within defense response to virus. Located in cytosol; euchromatin; and nucleoplasm. Part of exosome (RNase complex) and nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 19.8), kidney (RPKM 7.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EXOSC4 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144064056..144080648)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145239523..145241499)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145133575..145135551)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902039 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145106761-145107658 Neighboring gene 5-oxoprolinase, ATP-hydrolysing Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:145115803-145116323 Neighboring gene microRNA 6846 Neighboring gene uncharacterized LOC124902038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19654 Neighboring gene microRNA 6847 Neighboring gene glycosylphosphatidylinositol anchor attachment 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145144930-145145430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145145431-145145931 Neighboring gene Sharpr-MPRA regulatory region 12380 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145150053-145150248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28088 Neighboring gene cytochrome c1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20591

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT enables RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA deamination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maturation of 5.8S rRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nuclear mRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear mRNA surveillance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in poly(A)-dependent snoRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in rRNA processing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytoplasmic exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in euchromatin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of nucleolar exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    exosome complex component RRP41
    Names
    exosome complex exonuclease RRP41
    exosome component Rrp41
    ribosomal RNA-processing protein 41

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019037.3NP_061910.1  exosome complex component RRP41

      See identical proteins and their annotated locations for NP_061910.1

      Status: VALIDATED

      Source sequence(s)
      AK000598, BC002777, BM839994
      Consensus CDS
      CCDS6414.1
      UniProtKB/Swiss-Prot
      Q9NPD3
      Related
      ENSP00000315476.4, ENST00000316052.6
      Conserved Domains (1) summary
      cd11370
      Location:11237
      RNase_PH_RRP41; RRP41 subunit of eukaryotic exosome

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      144064056..144080648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517134.4XP_011515436.1  exosome complex component RRP41 isoform X1

      Conserved Domains (1) summary
      cl03114
      Location:1139
      RNase_PH; RNase PH-like 3'-5' exoribonucleases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      145239523..145241499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)