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    SMIM26 small integral membrane protein 26 [ Homo sapiens (human) ]

    Gene ID: 388789, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SMIM26provided by HGNC
    Official Full Name
    small integral membrane protein 26provided by HGNC
    Primary source
    HGNC:HGNC:43430
    See related
    Ensembl:ENSG00000232388 AllianceGenome:HGNC:43430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LINC00493
    Summary
    Enables protein kinase binding activity and transmembrane transporter binding activity. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 42.1), adrenal (RPKM 38.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SMIM26 in Genome Data Viewer
    Location:
    20p11.23
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (18567432..18569611)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (18618488..18620664)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18548076..18550255)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17591 Neighboring gene ribosomal protein S19 pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:18504796-18505995 Neighboring gene SEC23 homolog B, COPII coat complex component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17592 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:18547927-18548209 Neighboring gene uncharacterized LOC124904878 Neighboring gene Sharpr-MPRA regulatory region 13138 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:18568835-18569334 Neighboring gene RNA, 7SL, cytoplasmic 638, pseudogene Neighboring gene D-aminoacyl-tRNA deacylase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Investigation of LINC00493/SMIM26 Gene Suggests Its Dual Functioning at mRNA and Protein Level. Konina D, et al. Int J Mol Sci, 2021 Aug 6. PMID 34445188, Free PMC Article
    2. Identification and analysis of short open reading frames (sORFs) in the initially annotated noncoding RNA LINC00493 from human cells. Yeasmin F, et al. J Biochem, 2021 Apr 29. PMID 33386847
    3. LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma. Meng K, et al. EMBO Rep, 2023 Jun 5. PMID 37009826, Free PMC Article
    4. Co-expression Network Analysis of Human lncRNAs and Cancer Genes. Cogill SB, et al. Cancer Inform, 2014. PMID 25392693, Free PMC Article
    5. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma.
      Title: LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma.
    2. Investigation of LINC00493/SMIM26 Gene Suggests Its Dual Functioning at mRNA and Protein Level.
      Title: Investigation of LINC00493/SMIM26 Gene Suggests Its Dual Functioning at mRNA and Protein Level.
    3. Identification and analysis of short open reading frames (sORFs) in the initially annotated noncoding RNA LINC00493 from human cells.
      Title: Identification and analysis of short open reading frames (sORFs) in the initially annotated noncoding RNA LINC00493 from human cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20941

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small integral membrane protein 26
    Names
    long intergenic non-protein coding RNA 493

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348957.2 → NP_001335886.1  small integral membrane protein 26 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK024594
      Consensus CDS
      CCDS86936.1
      UniProtKB/Swiss-Prot
      A0A096LP01, A0A096LPB2
      Related
      ENSP00000485316.2, ENST00000411646.2

    2. NM_001348958.2 → NP_001335887.1  small integral membrane protein 26 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) has the same N- and C-terimi, but is one aa shorter than isoform 1.
      Source sequence(s)
      AL121900, BC092494, DR005796
      Consensus CDS
      CCDS86937.1
      Related
      ENSP00000485491.1, ENST00000435844.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      18567432..18569611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      18618488..18620664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_015432.1: Suppressed sequence

      Description
      NR_015432.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A096LP01.1 GenPept UniProtKB/Swiss-Prot:A0A096LP01

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials