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    RTN4R reticulon 4 receptor [ Homo sapiens (human) ]

    Gene ID: 65078, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RTN4Rprovided by HGNC
    Official Full Name
    reticulon 4 receptorprovided by HGNC
    Primary source
    HGNC:HGNC:18601
    See related
    Ensembl:ENSG00000040608 MIM:605566; AllianceGenome:HGNC:18601
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NGR; NOGOR
    Summary
    This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 7.7), spleen (RPKM 2.5) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RTN4R in Genome Data Viewer
    Location:
    22q11.21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (20241415..20268318, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (20621207..20649434, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20228938..20255841, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905083 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20210507-20211174 Neighboring gene uncharacterized LOC105372863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20218512-20219305 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20225493-20226085 Neighboring gene Sharpr-MPRA regulatory region 11316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20230230-20230822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18673 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20234375-20234965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20235693-20236294 Neighboring gene microRNA 1286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20243726-20244270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20254685-20255373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13487 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20262187-20262687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20269715-20270454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20270455-20271195 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20271196-20271935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20280047-20280548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20285530-20286031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13492 Neighboring gene proline dehydrogenase like, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20300941-20301496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20301497-20302050 Neighboring gene Sharpr-MPRA regulatory region 9836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13493 Neighboring gene DiGeorge syndrome critical region gene 6 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Associations between neurodevelopmental genes, neuroanatomy, and ultra high risk symptoms of psychosis in 22q11.2 deletion syndrome. Thompson CA, et al. Am J Med Genet B Neuropsychiatr Genet, 2017 Apr. PMID 28139055
    2. Neuronal overexpression of Nogo receptor 1 in APPswe/PSEN1(ΔE9) mice impairs spatial cognition tasks without influencing plaque formation. Karlsson TE, et al. J Alzheimers Dis, 2013. PMID 22903127
    3. Expression of Nogo-66 receptor in human astrocytoma is correlated with tumor malignancy. Xiong N, et al. Mol Biol Rep, 2012 Mar. PMID 21681431
    4. White matter abnormalities in 22q11.2 deletion syndrome: preliminary associations with the Nogo-66 receptor gene and symptoms of psychosis. Perlstein MD, et al. Schizophr Res, 2014 Jan. PMID 24321711, Free PMC Article
    5. Lack of association of the RTN4R genetic variations with risk of schizophrenia and SPEM abnormality in a Korean population. Pasaje CF, et al. Psychiatry Res, 2011 Sep 30. PMID 21377214

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development.
      Title: RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development.
    2. Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma.
      Title: Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma.
    3. the treatment of glioblastoma multiforme cells with TGFb1 suppressed NgR maturation. We showed that NgR and vimentin interact, which could be a possible mechanism for the suppression of NgR maturation.
      Title: Nogo receptor-vimentin interaction: a novel mechanism for the invasive activity of glioblastoma multiforme.
    4. SATB2 and NRG1 overexpression induced many of the signaling pathways.
      Title: SATB2 and NGR1: potential upstream regulatory factors in uterine leiomyomas.
    5. Nociceptin receptor ORL1 increases the cell surface expression of reticulon 4 receptor (NgR1) in HEK293T cells.
      Title: The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury.
    6. miR-10 can promote microglia cell proliferation and inhibit the inflammatory cytokine secretion via targeting the NgR gene to down-regulate its expression.
      Title: MiR-10 targets NgR to modulate the proliferation of microglial cells and the secretion of inflammatory cytokines.
    7. Results indicate an association between RTN4R genetic variation and phenotypes linked to prefrontal function. In an hierarchical approach, a SNP (rs696884) selected based on its association with RTN4R postmortem mRNA expression in the prefrontal cortex was shown to modulate prefrontal activity during working memory processing.
      Title: Genetic variation is associated with RTN4R expression and working memory processing in healthy humans.
    8. NgR1 ligand has a role in in oligodendrocyte progenitor cells fate in the context of a specific and common type of stroke
      Title: Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice.
    9. Allelic variation of the rs701428 SNP of RTN4R was significantly associated with volumetric differences in gray matter of the lingual gyrus and cuneus of the occipital lobe. Moreover, occipital gray matter volumes were robustly associated with ultra high risk symptoms of psychosis in the presence of the G allele of rs701428.
      Title: Associations between neurodevelopmental genes, neuroanatomy, and ultra high risk symptoms of psychosis in 22q11.2 deletion syndrome.
    10. Panax notoginseng saponins provide neuroprotective effects in a rat model of cerebral ischemia and SH-SY5Y cells exposed to oxygen/glucose deprivation injury by inhibiting the overexpression of NgR1, RhoA, and ROCK2.
      Title: Panax notoginseng saponins provide neuroprotection by regulating NgR1/RhoA/ROCK2 pathway expression, in vitro and in vivo.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Schizophrenia
    MedGen: C0036341 OMIM: 181500 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chondroitin sulfate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ganglioside GM1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ganglioside GM1 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ganglioside GT1b binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ganglioside GT1b binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neuregulin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in corpus callosum development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of axon regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuronal signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axonal growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendritic shaft ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    reticulon-4 receptor
    Names
    Nogo-66 receptor
    UNQ330/PRO526
    nogo receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012176.2 RefSeqGene

      Range
      4976..31879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_023004.6 → NP_075380.1  reticulon-4 receptor precursor

      See identical proteins and their annotated locations for NP_075380.1

      Status: REVIEWED

      Source sequence(s)
      AC007663, AL834449, BM762412
      Consensus CDS
      CCDS13777.1
      UniProtKB/Swiss-Prot
      D3DX28, Q9BZR6
      UniProtKB/TrEMBL
      H7C0V4
      Related
      ENSP00000043402.7, ENST00000043402.8
      Conserved Domains (4) summary
      sd00033
      Location:60 → 82
      LRR_RI; leucine-rich repeat [structural motif]
      pfam04094
      Location:332 → 417
      DUF390; Protein of unknown function (DUF390)
      pfam13855
      Location:156 → 214
      LRR_8; Leucine rich repeat
      cl15307
      Location:260 → 296
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      20241415..20268318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      20621207..20649434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BZR6.1 GenPept UniProtKB/Swiss-Prot:Q9BZR6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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