ZNF776 zinc finger protein 776 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF776provided by HGNC
Official Full Name: zinc finger protein 776provided by HGNC
Primary source: HGNC:HGNC:26765
See related: Ensembl:ENSG00000152443 AllianceGenome:HGNC:26765
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bone marrow (RPKM 5.3), lymph node (RPKM 4.3) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 19q13.43

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (57746815..57758148)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (60843753..60855084)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (58258183..58269516)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19S704E (e-PCR)
- UniSTS:150604

G18046 (e-PCR)
- UniSTS:63367

SHGC-24036 (e-PCR)
- UniSTS:61383

RH46392 (e-PCR)
- UniSTS:27094

Clone Names

FLJ30886, FLJ38288, DKFZp781G1213, DKFZp686K10134

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 776

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052796.1 RefSeqGene

Range

5020..16353

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001348007.2 → NP_001334936.1 zinc finger protein 776 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice structure in its 3' coding region, resulting in a translational frameshift and shorter 3' UTR, compared to variant 1. The encoded isoform (2) is substantially shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AK127764, AK299680, BX105932, DA534001

UniProtKB/Swiss-Prot

Q68DI1

UniProtKB/TrEMBL

B4DSC6

Conserved Domains (1) summary

pfam01352
Location:13 → 54

KRAB; KRAB box
NM_173632.4 → NP_775903.3 zinc finger protein 776 isoform 1

See identical proteins and their annotated locations for NP_775903.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AI446541, AK127764, AK299680, BC136753, CR936802

Consensus CDS

CCDS12962.2

UniProtKB/Swiss-Prot

Q68DI1, Q6ZS36, Q8N968

Related

ENSP00000321812.5, ENST00000317178.10

Conserved Domains (5) summary

smart00349
Location:14 → 55

KRAB; krueppel associated box

COG5048
Location:291 → 439

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:322 → 342

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:14 → 53

KRAB; KRAB box

pfam13465
Location:390 → 415

zf-H2C2_2; Zinc-finger double domain

RNA

NR_145326.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate exon structure near its 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK127764, AK299680, BX105932, DA534001
NR_145327.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate exon structure near its 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK127764, AK299680, BX105932, CR936802, DA534001
NR_145328.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate internal exon to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AK127764, BX105932, HY045891