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    DCN decorin [ Homo sapiens (human) ]

    Gene ID: 1634, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DCNprovided by HGNC
    Official Full Name
    decorinprovided by HGNC
    Primary source
    HGNC:HGNC:2705
    See related
    Ensembl:ENSG00000011465 MIM:125255; AllianceGenome:HGNC:2705
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B
    Summary
    This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
    Expression
    Broad expression in ovary (RPKM 562.9), gall bladder (RPKM 411.1) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DCN in Genome Data Viewer
    Location:
    12q21.33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (91140484..91182817, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (91117966..91160293, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (91534261..91576594, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratocan Neighboring gene VISTA enhancer hs2540 Neighboring gene lumican Neighboring gene uncharacterized LOC124903075 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:91666219-91666772 Neighboring gene uncharacterized LOC105369896 Neighboring gene uncharacterized LOC107984544

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Estimation of the binding force of the collagen molecule-decorin core protein complex in collagen fibril. Vesentini S, et al. J Biomech, 2005 Mar. PMID 15652541
    2. A role for aberrantly expressed nuclear localized decorin in migration and invasion of dysplastic and malignant oral epithelial cells. Dil N, et al. Head Neck Oncol, 2011 Sep 29. PMID 21958730, Free PMC Article
    3. Purification and characterization of decorin from the culture media of MRC-5 cells. Honda E, et al. Int J Biochem Cell Biol, 2004 Aug. PMID 15147741
    4. Decorin induced by progesterone plays a crucial role in suppressing endometriosis. Ono YJ, et al. J Endocrinol, 2014 Nov. PMID 25244916, Free PMC Article
    5. Differential expression and localization of decorin in human choriodecidual membrane during preterm and term pregnancy. Ogita K, et al. Am J Reprod Immunol, 2004 Mar. PMID 15209389

    See all (265) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decorin attenuates hypertrophic scar fibrosis via TGFbeta/Smad signalling.
      Title: Decorin attenuates hypertrophic scar fibrosis via TGFβ/Smad signalling.
    2. The effects of TGF-beta1 and IFN-alpha2b on decorin, decorin isoforms and type I collagen in hypertrophic scar dermal fibroblasts.
      Title: The effects of TGF-β1 and IFN-α2b on decorin, decorin isoforms and type I collagen in hypertrophic scar dermal fibroblasts.
    3. Maternally Expressed Gene 3 Negatively Regulated Decorin to Supresse Angiogenesis, Proliferation and Migration of Endothelial Cells.
      Title: Maternally Expressed Gene 3 Negatively Regulated Decorin to Supresse Angiogenesis, Proliferation and Migration of Endothelial Cells.
    4. The aberrant levels of decorin induce damages of human salivary gland epithelial cells and polarization of macrophages.
      Title: The aberrant levels of decorin induce damages of human salivary gland epithelial cells and polarization of macrophages.
    5. HBx downregulated decorin and decorin-derived peptides inhibit the proliferation and tumorigenicity of hepatocellular carcinoma cells.
      Title: HBx downregulated decorin and decorin-derived peptides inhibit the proliferation and tumorigenicity of hepatocellular carcinoma cells.
    6. The levels of peripheral blood TNF-alpha, Decorin and neutrophils MAPK1 mRNA levels of patients with preeclampsia and their clinical significance.
      Title: The levels of peripheral blood TNF-α, Decorin and neutrophils MAPK1 mRNA levels of patients with preeclampsia and their clinical significance.
    7. Resistance Exercise-Induced Increases in Muscle Myostatin mRNA and Protein Expression Are Subsequently Decreased in Circulation in the Presence of Increased Levels of the Extracellular Matrix Stabilizing Protein Decorin.
      Title: Resistance Exercise-Induced Increases in Muscle Myostatin mRNA and Protein Expression Are Subsequently Decreased in Circulation in the Presence of Increased Levels of the Extracellular Matrix Stabilizing Protein Decorin.
    8. Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.
      Title: Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.
    9. Serum Decorin, Biglycan, and Extracellular Matrix Component Expression in Preterm Birth.
      Title: Serum Decorin, Biglycan, and Extracellular Matrix Component Expression in Preterm Birth.
    10. Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases.
      Title: Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases.
    Submit: New GeneRIF Correction See all GeneRIFs (190)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Congenital stromal corneal dystrophy
    MedGen: C1864738 OMIM: 610048 GeneReviews: Congenital Stromal Corneal Dystrophy
    		Compare labs

    EBI GWAS Catalog

    Description
    GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables extracellular matrix binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular matrix structural constituent conferring compression resistance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables extracellular matrix structural constituent conferring compression resistance RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables glycosaminoglycan binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of vascular endothelial growth factor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of macroautophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of macroautophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of mitochondrial depolarization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of mitochondrial fission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
    		  
    colocalizes_with collagen-containing extracellular matrix HDA PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    colocalizes_with collagen-containing extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    decorin
    Names
    bone proteoglycan II
    dermatan sulphate proteoglycans II
    proteoglycan core protein
    small leucine-rich protein 1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011672.2 RefSeqGene

      Range
      5000..47333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001920.5 → NP_001911.1  decorin isoform a preproprotein

      See identical proteins and their annotated locations for NP_001911.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A1) represents the longest transcript and encodes the longest isoform. Both variants A1 and A2 encode the same isoform (a).
      Source sequence(s)
      AC007115, AW444736, BM672011, BX094949, BX571756, CD689331
      Consensus CDS
      CCDS9039.1
      UniProtKB/Swiss-Prot
      P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9
      UniProtKB/TrEMBL
      Q6FH10
      Related
      ENSP00000052754.5, ENST00000052754.10
      Conserved Domains (3) summary
      sd00033
      Location:62 → 82
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01462
      Location:54 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      cl26018
      Location:70 → 298
      NEL; C-terminal novel E3 ligase, LRR-interacting

    2. NM_133503.4 → NP_598010.1  decorin isoform a preproprotein

      See identical proteins and their annotated locations for NP_598010.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A2) differs in the 5' UTR compared to variant A1. Both variants A1 and A2 encode the same isoform (a).
      Source sequence(s)
      AC007115, AW444736, BM672011, BX094949, BX571756
      Consensus CDS
      CCDS9039.1
      UniProtKB/Swiss-Prot
      P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9
      UniProtKB/TrEMBL
      Q6FH10
      Conserved Domains (3) summary
      sd00033
      Location:62 → 82
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01462
      Location:54 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      cl26018
      Location:70 → 298
      NEL; C-terminal novel E3 ligase, LRR-interacting

    3. NM_133504.3 → NP_598011.1  decorin isoform b precursor

      See identical proteins and their annotated locations for NP_598011.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) differs in the 5' UTR and lacks two alternate exons in the coding region compared to variant A1. The encoded isoform (b) is shorter than isoform a. This isoform (b) may undergo proteolytic processing similar to isoform a.
      Source sequence(s)
      AC007115, AF138301, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
      Consensus CDS
      CCDS9040.1
      UniProtKB/Swiss-Prot
      P07585
      UniProtKB/TrEMBL
      Q6FH10
      Related
      ENSP00000413723.2, ENST00000420120.6
      Conserved Domains (4) summary
      smart00013
      Location:54 → 77
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:70 → 92
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:112 → 172
      LRR_8; Leucine rich repeat
      cl26793
      Location:70 → 196
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    4. NM_133505.3 → NP_598012.1  decorin isoform c precursor

      See identical proteins and their annotated locations for NP_598012.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (C) differs in the 5' UTR and lacks three alternate exons in the coding region compared to variant A1. The encoded isoform (c) is shorter than isoform a. This isoform (c) may undergo proteolytic processing similar to isoform a.
      Source sequence(s)
      AC007115, AF138302, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
      Consensus CDS
      CCDS9041.1
      UniProtKB/TrEMBL
      F8VNV6
      Related
      ENSP00000401021.1, ENST00000425043.5
      Conserved Domains (3) summary
      smart00013
      Location:54 → 76
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:76 → 99
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:74 → 134
      LRR_8; Leucine rich repeat

    5. NM_133506.3 → NP_598013.1  decorin isoform d precursor

      See identical proteins and their annotated locations for NP_598013.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (D) differs in the 5' UTR and lacks four alternate exons in the coding region compared to variant A1. The encoded isoform (d) is shorter than isoform a. This isoform (d) may undergo proteolytic processing similar to isoform a.
      Source sequence(s)
      AC007115, AF138303, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
      Consensus CDS
      CCDS9042.1
      UniProtKB/TrEMBL
      A0A0S2Z3L8
      Related
      ENSP00000399815.2, ENST00000441303.6
      Conserved Domains (3) summary
      smart00013
      Location:54 → 85
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:62 → 82
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:84 → 125
      LRR_8; Leucine rich repeat

    6. NM_133507.3 → NP_598014.1  decorin isoform e precursor

      See identical proteins and their annotated locations for NP_598014.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (E) differs in the 5' UTR and lacks five alternate exons in the coding region compared to variant A1. The encoded isoform (e) is shorter than isoform a. This isoform (e) may undergo proteolytic processing similar to isoform a.
      Source sequence(s)
      AC007115, AF138304, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
      Consensus CDS
      CCDS44951.1
      UniProtKB/TrEMBL
      A0A7I2PRI8
      Related
      ENSP00000398514.2, ENST00000456569.2
      Conserved Domains (1) summary
      cl02423
      Location:54 → 71
      LRRNT; Leucine rich repeat N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      91140484..91182817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      91117966..91160293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07585.1 GenPept UniProtKB/Swiss-Prot:P07585

    Gene LinkOut

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