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    ZNF780B zinc finger protein 780B [ Homo sapiens (human) ]

    Gene ID: 163131, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF780Bprovided by HGNC
    Official Full Name
    zinc finger protein 780Bprovided by HGNC
    Primary source
    HGNC:HGNC:33109
    See related
    Ensembl:ENSG00000128000 AllianceGenome:HGNC:33109
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF779
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.6), ovary (RPKM 2.0) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF780B in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (40028260..40056231, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42848466..42876439, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40534167..40562138, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:40502617-40503116 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10615 Neighboring gene zinc finger protein 546 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:40520495-40521694 Neighboring gene PAT1 homolog 1, processing body mRNA decay factor pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:40541448-40542647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14637 Neighboring gene zinc finger protein 780A Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:40596583-40597124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14638 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:40613086-40613650 Neighboring gene uncharacterized LOC124904803

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
    2. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 780B
    Names
    zinc finger protein 779

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005851.3 → NP_001005851.1  zinc finger protein 780B

      See identical proteins and their annotated locations for NP_001005851.1

      Status: VALIDATED

      Source sequence(s)
      AC005614, AC007842, BC136960, CB053507
      Consensus CDS
      CCDS46077.1
      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6
      Related
      ENSP00000391641.1, ENST00000434248.6
      Conserved Domains (4) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:191 → 632
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:615 → 635
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:740 → 764
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      40028260..40056231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258591.6 → XP_005258648.1  zinc finger protein 780B isoform X1

      See identical proteins and their annotated locations for XP_005258648.1

      Conserved Domains (5) summary
      smart00349
      Location:6 → 67
      KRAB; krueppel associated box
      COG5048
      Location:192 → 633
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:336 → 356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:377 → 401
      zf-H2C2_2; Zinc-finger double domain

    2. XM_017026426.2 → XP_016881915.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6
      Conserved Domains (4) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:191 → 632
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:615 → 635
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:740 → 764
      zf-H2C2_2; Zinc-finger double domain

    3. XM_047438337.1 → XP_047294293.1  zinc finger protein 780B isoform X1

    4. XM_017026425.3 → XP_016881914.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6
      Conserved Domains (4) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:191 → 632
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:615 → 635
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:740 → 764
      zf-H2C2_2; Zinc-finger double domain

    5. XM_006723072.5 → XP_006723135.1  zinc finger protein 780B isoform X1

      See identical proteins and their annotated locations for XP_006723135.1

      Conserved Domains (5) summary
      smart00349
      Location:6 → 67
      KRAB; krueppel associated box
      COG5048
      Location:192 → 633
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:336 → 356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:377 → 401
      zf-H2C2_2; Zinc-finger double domain

    6. XM_017026427.2 → XP_016881916.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6
      Conserved Domains (4) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:191 → 632
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:615 → 635
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:740 → 764
      zf-H2C2_2; Zinc-finger double domain

    7. XM_005258595.4 → XP_005258652.1  zinc finger protein 780B isoform X1

      See identical proteins and their annotated locations for XP_005258652.1

      Conserved Domains (5) summary
      smart00349
      Location:6 → 67
      KRAB; krueppel associated box
      COG5048
      Location:192 → 633
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:336 → 356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:377 → 401
      zf-H2C2_2; Zinc-finger double domain

    8. XM_047438340.1 → XP_047294296.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    9. XM_005258592.4 → XP_005258649.1  zinc finger protein 780B isoform X1

      See identical proteins and their annotated locations for XP_005258649.1

      Conserved Domains (5) summary
      smart00349
      Location:6 → 67
      KRAB; krueppel associated box
      COG5048
      Location:192 → 633
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:336 → 356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:377 → 401
      zf-H2C2_2; Zinc-finger double domain

    10. XM_005258593.3 → XP_005258650.1  zinc finger protein 780B isoform X2

      See identical proteins and their annotated locations for XP_005258650.1

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6
      Conserved Domains (4) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:191 → 632
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:615 → 635
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:740 → 764
      zf-H2C2_2; Zinc-finger double domain

    11. XM_005258590.5 → XP_005258647.1  zinc finger protein 780B isoform X1

      See identical proteins and their annotated locations for XP_005258647.1

      Conserved Domains (5) summary
      smart00349
      Location:6 → 67
      KRAB; krueppel associated box
      COG5048
      Location:192 → 633
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:336 → 356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:377 → 401
      zf-H2C2_2; Zinc-finger double domain

    12. XM_047438342.1 → XP_047294298.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    13. XM_011526593.3 → XP_011524895.1  zinc finger protein 780B isoform X1

      See identical proteins and their annotated locations for XP_011524895.1

      Conserved Domains (5) summary
      smart00349
      Location:6 → 67
      KRAB; krueppel associated box
      COG5048
      Location:192 → 633
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:336 → 356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:377 → 401
      zf-H2C2_2; Zinc-finger double domain

    14. XM_047438341.1 → XP_047294297.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    15. XM_047438339.1 → XP_047294295.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    16. XM_047438338.1 → XP_047294294.1  zinc finger protein 780B isoform X1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646206.1 Reference GRCh38.p14 PATCHES

      Range
      303403..331374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331620.1 → XP_054187595.1  zinc finger protein 780B isoform X1

    2. XM_054331628.1 → XP_054187603.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    3. XM_054331621.1 → XP_054187596.1  zinc finger protein 780B isoform X1

    4. XM_054331627.1 → XP_054187602.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    5. XM_054331619.1 → XP_054187594.1  zinc finger protein 780B isoform X1

    6. XM_054331629.1 → XP_054187604.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    7. XM_054331622.1 → XP_054187597.1  zinc finger protein 780B isoform X1

    8. XM_054331630.1 → XP_054187605.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    9. XM_054331626.1 → XP_054187601.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    10. XM_054331623.1 → XP_054187598.1  zinc finger protein 780B isoform X1

    11. XM_054331631.1 → XP_054187606.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    12. XM_054331632.1 → XP_054187607.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    13. XM_054331633.1 → XP_054187608.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    14. XM_054331625.1 → XP_054187600.1  zinc finger protein 780B isoform X1

    15. XM_054331624.1 → XP_054187599.1  zinc finger protein 780B isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      42848466..42876439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320067.1 → XP_054176042.1  zinc finger protein 780B isoform X1

    2. XM_054320075.1 → XP_054176050.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    3. XM_054320068.1 → XP_054176043.1  zinc finger protein 780B isoform X1

    4. XM_054320074.1 → XP_054176049.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    5. XM_054320066.1 → XP_054176041.1  zinc finger protein 780B isoform X1

    6. XM_054320076.1 → XP_054176051.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    7. XM_054320069.1 → XP_054176044.1  zinc finger protein 780B isoform X1

    8. XM_054320077.1 → XP_054176052.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    9. XM_054320073.1 → XP_054176048.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    10. XM_054320070.1 → XP_054176045.1  zinc finger protein 780B isoform X1

    11. XM_054320078.1 → XP_054176053.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    12. XM_054320079.1 → XP_054176054.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    13. XM_054320080.1 → XP_054176055.1  zinc finger protein 780B isoform X2

      UniProtKB/Swiss-Prot
      B9EH00, Q9Y6R6

    14. XM_054320072.1 → XP_054176047.1  zinc finger protein 780B isoform X1

    15. XM_054320071.1 → XP_054176046.1  zinc finger protein 780B isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y6R6.1 GenPept UniProtKB/Swiss-Prot:Q9Y6R6

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