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    DUT1 bifunctional dITP/dUTP diphosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852554, updated on 17-May-2024

    Summary

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    Gene symbol
    DUT1
    Gene description
    bifunctional dITP/dUTP diphosphatase
    Primary source
    FungiDB:YBR252W
    Locus tag
    YBR252W
    See related
    SGD:S000000456; AllianceGenome:SGD:S000000456; VEuPathDB:YBR252W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables dITP diphosphatase activity and dUTP diphosphatase activity. Involved in dITP catabolic process and dUTP catabolic process. Located in cytoplasm and nucleus. Used to study cancer. Orthologous to human DUT (deoxyuridine triphosphatase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DUT1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (722611..723054)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Spo23p Neighboring gene mitochondrial 37S ribosomal protein MRPS5 Neighboring gene Srb6p Neighboring gene TRAPP subunit TRS20

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme. Tchigvintsev A, et al. Biochem J, 2011 Jul 15. PMID 21548881, Free PMC Article
    2. The complete sequence of a 6794 bp segment located on the right arm of chromosome II of Saccharomyces cerevisiae. Finding of a putative dUTPase in a yeast. Doignon F, et al. Yeast, 1993 Oct. PMID 8256522
    3. Homologous recombination is stimulated by a decrease in dUTPase in Arabidopsis. Dubois E, et al. PLoS One, 2011 Apr 26. PMID 21541310, Free PMC Article
    4. dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae. Gadsden MH, et al. EMBO J, 1993 Nov. PMID 8223452, Free PMC Article
    5. Transcription of genes encoding enzymes involved in DNA synthesis during the cell cycle of Saccharomyces cerevisiae. McIntosh EM, et al. Mol Gen Genet, 1986 Sep. PMID 3020375

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structure of DUT1 and site-directed mutagenesis support a role of the conserved Phe142 in the interaction with the uracil base.
      Title: Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme.
    2. Dut1 plays a central role in the prevention of the formation of endogenous DNA damage.
      Title: dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables dITP diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dUTP diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dUTP diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dUTP diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dUTP diphosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dITP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dUMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dUMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dUTP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dUTP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dUTP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dUTP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine deoxyribonucleoside triphosphate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    bifunctional dITP/dUTP diphosphatase
    NP_009811.3
    • Deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate; human homolog DUT allows growth of yeast haploid dut1 null mutant after sporulation of heterozygous diploid

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      722611..723054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178600.3 → NP_009811.3  TPA: bifunctional dITP/dUTP diphosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009811.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQP8, P33317
      UniProtKB/TrEMBL
      A0A8H4BUK8, A6ZLJ1, B3LMR0, C7GMX9, D3UEZ9, G2W9Q5, N1P8T1
      Conserved Domains (1) summary
      TIGR00576
      Location:9 → 146
      dut; deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33317.2

    Gene LinkOut

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