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    RUP1 Rup1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854306, updated on 7-Jul-2024

    Summary

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    Gene symbol
    RUP1
    Gene description
    Rup1p
    Primary source
    FungiDB:YOR138C
    Locus tag
    YOR138C
    See related
    SGD:S000005664; AllianceGenome:SGD:S000005664; VEuPathDB:YOR138C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in positive regulation of protein autoubiquitination and protein deubiquitination. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RUP1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (584309..586324, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase (NAD(+)) IDH2 Neighboring gene Sia1p Neighboring gene Sfl1p Neighboring gene Arp8p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubp2 regulates Rsp5 ubiquitination activity in vivo and in vitro. Lam MH, et al. PLoS One, 2013. PMID 24069405, Free PMC Article
    2. Guanine nucleotide-binding protein (Gα) endocytosis by a cascade of ubiquitin binding domain proteins is required for sustained morphogenesis and proper mating in yeast. Dixit G, et al. J Biol Chem, 2014 May 23. PMID 24722989, Free PMC Article
    3. Interaction of the deubiquitinating enzyme Ubp2 and the e3 ligase Rsp5 is required for transporter/receptor sorting in the multivesicular body pathway. Lam MH, et al. PLoS One, 2009. PMID 19165343, Free PMC Article
    4. Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies. Ren J, et al. Mol Biol Cell, 2007 Jan. PMID 17079730, Free PMC Article
    5. The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme. Kee Y, et al. EMBO J, 2005 Jul 6. PMID 15933713, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rup1p
    NP_014781.1
    • Protein that regulates ubiquitination of Rsp5p; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      584309..586324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183557.1 → NP_014781.1  TPA: Rup1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014781.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2J5, Q12242
      UniProtKB/TrEMBL
      A0A8H4BX05, G2WN12, N1NWM7
      Conserved Domains (1) summary
      cd14307
      Location:4 → 41
      UBA_RUP1p; UBA domain found in yeast UBA domain-containing protein RUP1p and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12242.1

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