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    SSF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856463, updated on 11-Sep-2024

    Summary

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    Official Symbol
    SSF1
    Primary source
    SGD:S000001108
    Locus tag
    YHR066W
    See related
    AllianceGenome:SGD:S000001108; FungiDB:YHR066W; VEuPathDB:YHR066W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables rRNA binding activity. Involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal large subunit assembly. Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to several human genes including PPAN-P2RY11 (PPAN-P2RY11 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (229335..230696)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Ssz1p Neighboring gene RNA-dependent ATPase RRP3 Neighboring gene hydroxyacyl-thioester dehydratase HTD2 Neighboring gene deoxyhypusine synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A nucleolar protein that affects mating efficiency in Saccharomyces cerevisiae by altering the morphological response to pheromone. Kim J, et al. Genetics, 1998 Jun. PMID 9611192, Free PMC Article
    2. Increased RNA production in Saccharomyces cerevisiae by simultaneously overexpressing FHL1, IFH1, and SSF2 and deleting HRP1. Guo X, et al. Appl Microbiol Biotechnol, 2020 Sep. PMID 32715361
    3. Identification of SSF1, CNS1, and HCH1 as multicopy suppressors of a Saccharomyces cerevisiae Hsp90 loss-of-function mutation. Nathan DF, et al. Proc Natl Acad Sci U S A, 1999 Feb 16. PMID 9990037, Free PMC Article
    4. Differential effects of Cdc68 on cell cycle-regulated promoters in Saccharomyces cerevisiae. Lycan D, et al. Mol Cell Biol, 1994 Nov. PMID 7935460, Free PMC Article
    5. An essential gene pair in Saccharomyces cerevisiae with a potential role in mating. Yu Y, et al. DNA Cell Biol, 1995 May. PMID 7748491

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell size HMP PubMed 
    involved_in ribosomal large subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rRNA-binding ribosome biosynthesis protein
    NP_011933.1
    • Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      229335..230696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179196.1 → NP_011933.1  TPA: rRNA-binding ribosome biosynthesis protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011933.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL15, P38789
      UniProtKB/TrEMBL
      A6ZSX2, C8Z9K4, G2WFD8, N1P113
      Conserved Domains (1) summary
      smart00879
      Location:26 → 220
      Brix; The Brix domain is found in a number of eukaryotic proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38789.1

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