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    KTR1 alpha-1,2-mannosyltransferase KTR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854266, updated on 4-Aug-2024

    Summary

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    Gene symbol
    KTR1
    Gene description
    alpha-1,2-mannosyltransferase KTR1
    Primary source
    FungiDB:YOR099W
    Locus tag
    YOR099W
    See related
    SGD:S000005625; AllianceGenome:SGD:S000005625; VEuPathDB:YOR099W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alpha-1,2-mannosyltransferase activity. Involved in protein N-linked glycosylation and protein O-linked glycosylation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See KTR1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (511825..513006)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene FG-nucleoporin NUP1 Neighboring gene carnitine:acyl carnitine antiporter Neighboring gene Ras family GTPase RAS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ktr1p is an alpha-1,2-mannosyltransferase of Saccharomyces cerevisiae. Comparison of the enzymic properties of soluble recombinant Ktr1p and Kre2p/Mnt1p produced in Pichia pastoris. Romero PA, et al. Biochem J, 1997 Jan 15. PMID 9020857, Free PMC Article
    2. The Ktr1p, Ktr3p, and Kre2p/Mnt1p mannosyltransferases participate in the elaboration of yeast O- and N-linked carbohydrate chains. Lussier M, et al. J Biol Chem, 1997 Jun 13. PMID 9182588
    3. Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism. Lussier M, et al. Yeast, 1997 Mar 15. PMID 9090056
    4. Functional characterization of the YUR1, KTR1, and KTR2 genes as members of the yeast KRE2/MNT1 mannosyltransferase gene family. Lussier M, et al. J Biol Chem, 1996 May 3. PMID 8631921
    5. Distinct adaptor proteins assist exit of Kre2-family proteins from the yeast ER. Noda Y, et al. Biol Open, 2014 Mar 15. PMID 24585773, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,2-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,2-mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell wall mannoprotein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,2-mannosyltransferase KTR1
    NP_014742.1
    • Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      511825..513006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183518.1 → NP_014742.1  TPA: alpha-1,2-mannosyltransferase KTR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014742.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2G0, P27810
      UniProtKB/TrEMBL
      A6ZNU9, B3LJE5, G2WMX6, N1NWY1
      Conserved Domains (1) summary
      COG5020
      Location:1 → 389
      KTR1; Mannosyltransferase [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27810.1

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