Ins1 insulin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ins1provided by RGD
Official Full Name: insulin 1provided by RGD
Primary source: RGD:2915
See related: EnsemblRapid:ENSRNOG00000012052 AllianceGenome:RGD:2915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables insulin receptor binding activity. Involved in response to cAMP; response to cytokine; and response to peptide hormone. Located in extracellular space. Colocalizes with cytoplasm. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 128.8) and Liver (RPKM 39.5) See more
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Genomic context

Location:: 1q55

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (261186119..261186686)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (251244973..251245540)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (272799784..272800351)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1.
Title: RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1.
Exogenous Ghrelin Increases Plasma Insulin Level in Diabetic Rats.
Title: Exogenous Ghrelin Increases Plasma Insulin Level in Diabetic Rats.
Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats.
Title: Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats.
These results suggest that CPG16 plays a role in the suppression of insulin gene expression in pancreatic beta-cells under glucotoxic conditions.
Title: Candidate plasticity gene 16 mediates suppression of insulin gene expression in rat insulinoma INS-1 cells under glucotoxic conditions.
NPB and NPBW1 mRNA was expressed in INS1E cells and rat pancreatic islets. In INS1E cells, NPB enhanced insulin 1 mRNA expression via an ERK1/2dependent mechanism
Title: Neuropeptide B stimulates insulin secretion and expression but not proliferation in rat insulin‑producing INS‑1E cells.
BHLHE40 is required for insulin induction of SREBP-1c mRNA in rodent liver.
Title: BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver.
Nociceptin co-localized only with insulin in pancreatic beta cells.
Title: Effect of nociceptin on insulin release in normal and diabetic rat pancreas.
characterized the phosphoproteome that is regulated by insulin as well as its key downstream kinases including Akt, mTORC1, and S6K.
Title: Global Phosphoproteomic Analysis of Insulin/Akt/mTORC1/S6K Signaling in Rat Hepatocytes.
In conclusion, TRPV4 differently regulates insulin mRNA expression in INS-1E cells via ERK1/2 and NO-dependent mechanisms.
Title: TRPV4 regulates insulin mRNA expression and INS-1E cell death via ERK1/2 and NO-dependent mechanisms.
CART is important for maintaining the beta-cell phenotype.
Title: Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes.

Submit: New GeneRIF Correction See all GeneRIFs (109)

General gene information

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Markers

PMC24644P6 (e-PCR)
- UniSTS:265494

Ins1 (e-PCR), detects polymorphism
- UniSTS:265494

D1Ztm3 (e-PCR)
- UniSTS:517928

D1Ztm5 (e-PCR)
- UniSTS:517932

D1Ztm4 (e-PCR)
- UniSTS:517938

D1Ztm6 (e-PCR)
- UniSTS:517940

PMC123023P1 (e-PCR)
- UniSTS:270422

PMC123023P3 (e-PCR)
- UniSTS:270424

PMC21231P1 (e-PCR)
- UniSTS:272021

PMC21334P1 (e-PCR)
- UniSTS:272036

Ins1 (e-PCR), detects polymorphism
- UniSTS:256685

AA986540 (e-PCR)
- UniSTS:179680

Ins2 (e-PCR), detects polymorphism
- UniSTS:259556

RH94799 (e-PCR)
- UniSTS:120046

Ins2 (e-PCR), detects polymorphism
- UniSTS:143600

UniSTS:267003 (e-PCR)
- UniSTS:267003

Ins1 (e-PCR), detects polymorphism
- UniSTS:267003

Ins1 (e-PCR), detects polymorphism
- UniSTS:516606

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oxygen-containing compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_positive_effect receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to dimethyl sulfoxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: insulin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019129.3 → NP_062002.1 insulin-1 preproprotein

See identical proteins and their annotated locations for NP_062002.1

Status: VALIDATED

Source sequence(s)

BP465191, BP502578

UniProtKB/Swiss-Prot

P01322

UniProtKB/TrEMBL

A6JHT1, A6JHT2

Related

ENSRNOP00000016052.3, ENSRNOT00000016052.7

Conserved Domains (1) summary

cd04367
Location:26 → 110

IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...