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    Zfp354a zinc finger protein 354A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24522, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Zfp354aprovided by RGD
    Official Full Name
    zinc finger protein 354Aprovided by RGD
    Primary source
    RGD:2967
    See related
    EnsemblRapid:ENSRNOG00000003634 AllianceGenome:RGD:2967
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kid1; Tcf17; Znf354a
    Summary
    Enables DNA-binding transcription factor activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nucleolar fragmentation; and response to folic acid. Located in nucleolus. Orthologous to human ZNF354A (zinc finger protein 354A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 130.4), Liver (RPKM 43.2) and 9 other tissues See more
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    Genomic context

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    See Zfp354a in Genome Data Viewer
    Location:
    10q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (35897217..35909063)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (35396242..35408069)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (36586495..36600172)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480783 Neighboring gene olfactory receptor family 1 subfamily X member 2D Neighboring gene olfactory receptor family 1 subfamily N member 2 like, pseudogene 1 Neighboring gene uncharacterized LOC134480784 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC102546326

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Kid-1 participates in regulating ERK phosphorylation as a part of the circadian clock output in rat kidney. Yamato M, et al. J Recept Signal Transduct Res, 2009. PMID 19519174
    2. Differential expression of the zinc finger gene TCF17 in testicular tumors. Przyborski SA, et al. Cancer Res, 1998 Oct 15. PMID 9788609
    3. Genomic structure and chromosomal location of the rat gene encoding the zinc finger transcription factor Kid-1. Witzgall R, et al. Genomics, 1994 Mar 15. PMID 8020966
    4. Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury. Witzgall R, et al. Mol Cell Biol, 1993 Mar. PMID 8382778, Free PMC Article
    5. Expression of the transcriptional repressor protein Kid-1 leads to the disintegration of the nucleolus. Huang Z, et al. J Biol Chem, 1999 Mar 19. PMID 10075651

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. clock-controlled Kid-1 regulates the cell cycle of proliferating renal tubular epithelial cells through ERK phosphorylation.
      Title: Kid-1 participates in regulating ERK phosphorylation as a part of the circadian clock output in rat kidney.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in kidney development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleolus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to folic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 354A
    Names
    Kidney 1
    TCF-17
    kidney, ischemia, and developmentally-regulated protein 1
    renal transcription factor Kid-1
    transcription factor 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429899.1 → NP_001416828.1  zinc finger protein 354A isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q02975
      UniProtKB/TrEMBL
      A6HE43

    2. NM_001429900.1 → NP_001416829.1  zinc finger protein 354A isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      Q6AZ27

    3. NM_001429901.1 → NP_001416830.1  zinc finger protein 354A isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      Q6AZ27

    4. NM_001429902.1 → NP_001416831.1  zinc finger protein 354A isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8L2QNR3

    5. NM_001429903.1 → NP_001416832.1  zinc finger protein 354A isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8L2QNR3

    6. NM_052798.4 → NP_434685.1  zinc finger protein 354A isoform a

      See identical proteins and their annotated locations for NP_434685.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q02975
      UniProtKB/TrEMBL
      A6HE43
      Related
      ENSRNOP00000092943.2, ENSRNOT00000097835.2
      Conserved Domains (5) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:170 → 567
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:467 → 487
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:339 → 364
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      35897217..35909063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767660.4 → XP_008765882.1  zinc finger protein 354A isoform X1

      Related
      ENSRNOP00000070798.2, ENSRNOT00000085203.3
      Conserved Domains (5) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:169 → 566
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:466 → 486
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:338 → 363
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039085190.2 → XP_038941118.1  zinc finger protein 354A isoform X2

      Related
      ENSRNOP00000049437.4, ENSRNOT00000045596.6
      Conserved Domains (3) summary
      smart00349
      Location:14 → 56
      KRAB; krueppel associated box
      COG5048
      Location:137 → 534
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:434 → 454
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02975.1 GenPept UniProtKB/Swiss-Prot:Q02975

    Gene LinkOut

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