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    Myrf myelin regulatory factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293736, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Myrfprovided by RGD
    Official Full Name
    myelin regulatory factorprovided by RGD
    Primary source
    RGD:1306622
    See related
    EnsemblRapid:ENSRNOG00000028274 AllianceGenome:RGD:1306622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrf; RGD1306622
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Predicted to be involved in several processes, including central nervous system myelin maintenance; positive regulation of myelination; and regulation of transcription, DNA-templated. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in endoplasmic reticulum membrane and nucleus. Orthologous to human MYRF (myelin regulatory factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 49.8), Lung (RPKM 39.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myrf in Genome Data Viewer
    Location:
    1q43
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216279057..216311155, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (206854175..206886276, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226260558..226292650, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene fatty acid desaturase 1 Neighboring gene transmembrane protein 258 Neighboring gene flap structure-specific endonuclease 1 Neighboring gene diacylglycerol lipase, alpha Neighboring gene ribosomal protein L10, pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Large-Scale Targeted Sequencing Study of Ischemic Stroke in the Han Chinese Population. Shi M, et al. J Am Heart Assoc, 2022 Oct 4. PMID 36193932, Free PMC Article
    2. Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia. Gawlińska K, et al. Int J Mol Sci, 2020 Oct 27. PMID 33120991, Free PMC Article
    3. Oligodendroglia Are Particularly Vulnerable to Oxidative Damage after Neurotrauma In Vivo. Giacci MK, et al. J Neurosci, 2018 Jul 18. PMID 29915135, Free PMC Article
    4. Co-transplantation of MRF-overexpressing oligodendrocyte precursor cells and Schwann cells promotes recovery in rat after spinal cord injury. Xie XM, et al. Neurobiol Dis, 2016 Oct. PMID 27370227
    5. Truncation mutations in MYRF underlie primary angle closure glaucoma. Ouyang J, et al. Hum Genet, 2023 Jan. PMID 36129575

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system myelin maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system myelin maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of oligodendrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autoprocessing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autoprocessing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cocaine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to immobilization stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myelin regulatory factor
    Names
    myelin gene regulatory factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170487.1 → NP_001163958.1  myelin regulatory factor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6ACZ2, D4A352
      Conserved Domains (5) summary
      pfam05224
      Location:392 → 539
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:586 → 646
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:666 → 701
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:1007 → 1138
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2
      cl01455
      Location:278 → 331
      PhnH; Bacterial phosphonate metabolizm protein (PhnH)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      216279057..216311155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231030.5 → XP_006231092.1  myelin regulatory factor isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACZ2
      Related
      ENSRNOP00000035676.6, ENSRNOT00000039133.7
      Conserved Domains (5) summary
      pfam05224
      Location:392 → 539
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:586 → 646
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:666 → 701
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:1006 → 1137
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2
      cl01455
      Location:278 → 331
      PhnH; Bacterial phosphonate metabolizm protein (PhnH)

    2. XM_063286961.1 → XP_063143031.1  myelin regulatory factor isoform X5

    3. XM_008760221.3 → XP_008758443.1  myelin regulatory factor isoform X4

      UniProtKB/TrEMBL
      A0A8I6ARG5
      Related
      ENSRNOP00000092057.2, ENSRNOT00000114113.2
      Conserved Domains (5) summary
      pfam05224
      Location:304 → 451
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:498 → 558
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:578 → 613
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:919 → 1050
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2
      cl01455
      Location:190 → 243
      PhnH; Bacterial phosphonate metabolizm protein (PhnH)

    4. XM_008760220.3 → XP_008758442.1  myelin regulatory factor isoform X3

      UniProtKB/TrEMBL
      A0A8I6ACZ2
      Conserved Domains (6) summary
      TIGR02600
      Location:768 → 866
      Verru_Chthon_A; Verru_Chthon cassette protein A
      pfam05224
      Location:392 → 539
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:586 → 646
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:666 → 701
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:979 → 1110
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2
      cl01455
      Location:278 → 331
      PhnH; Bacterial phosphonate metabolizm protein (PhnH)

    5. XM_006231031.4 → XP_006231093.1  myelin regulatory factor isoform X2

      UniProtKB/TrEMBL
      A0A8I6ACZ2, A0A8I6AIU7
      Related
      ENSRNOP00000095013.1, ENSRNOT00000094966.2
      Conserved Domains (6) summary
      TIGR02600
      Location:768 → 867
      Verru_Chthon_A; Verru_Chthon cassette protein A
      pfam05224
      Location:392 → 539
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:586 → 646
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:666 → 701
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:980 → 1111
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2
      cl01455
      Location:278 → 331
      PhnH; Bacterial phosphonate metabolizm protein (PhnH)
    Nucleotide Protein Strain
    Heading Accession and Version

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