Myh9 myosin, heavy chain 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Myh9provided by RGD
Full Name: myosin, heavy chain 9provided by RGD
Primary source: RGD:3140
See related: EnsemblRapid:ENSRNOG00000049236 AllianceGenome:RGD:3140
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NMIIA; Myh9l1
Summary: Enables several functions, including G-protein alpha-subunit binding activity; follicle-stimulating hormone receptor binding activity; and scaffold protein binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; actin cytoskeleton organization; and positive regulation of cell communication. Located in several cellular components, including actin filament; brush border; and lateral plasma membrane. Part of protein-containing complex. Colocalizes with endosome and phagocytic vesicle. Biomarker of metabolic acidosis. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and orofacial cleft. Orthologous to human MYH9 (myosin heavy chain 9). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: Gene ID:100911597 and GeneID:25745 on Rnor_6.0 are nearly identical to each other, and are both annotated on chromosome 7. This duplication is likely the result of a genome assembly error, and GeneID:100911597 is thought to better represent the Myh9 locus. [06 Apr 2015]; Note: Gene ID:100911597 and GeneID:25745 on Rnor_6.0 are nearly identical to each other, and are both annotated on chromosome 7. This duplication is likely the result of a genome assembly error, and GeneID:100911597 is thought to better represent the Myh9 locus. [08 Apr 2015]
Expression: Biased expression in Spleen (RPKM 1392.6), Lung (RPKM 1281.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (111224291..111304963, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (109343718..109424457, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (118740005..118792507, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Role of the C-Terminal Lysine of S100P in S100P-Induced Cell Migration and Metastasis.
Title: The Role of the C-Terminal Lysine of S100P in S100P-Induced Cell Migration and Metastasis.
NMMHC IIA triggers neuronal autophagic cell death by promoting F-actin-dependent ATG9A trafficking in cerebral ischemia/reperfusion.
Title: NMMHC IIA triggers neuronal autophagic cell death by promoting F-actin-dependent ATG9A trafficking in cerebral ischemia/reperfusion.
Results suggest that coupling between actin and microtubule cytoskeletons driven by Myosin II and KIF20A ensures the spatial coordination between RAB6-positive vesicles fission from Golgi/trans-Golgi network membranes and their exit along microtubules.
Title: Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions.
Angiotensin II-mediated MYH9 downregulation causes structural and functional podocyte injury in diabetic kidney disease.
Title: Angiotensin II-mediated MYH9 downregulation causes structural and functional podocyte injury in diabetic kidney disease.
constitutively forms a ternary complex with FSH-R and inactive GDP-bound G alpha h
Title: Nonmuscle myosin IIA (myosin heavy polypeptide 9): a novel class of signal transducer mediating the activation of G alpha h/phospholipase C-delta 1 pathway.
NMHC-IIA is functionally linked to megalin by interaction with Dab2 and is likely involved in megalin-mediated endocytosis in proximal tubule cells.
Title: Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells.
Expression of Myh9 in the rat cochlea: localization within the stereocilia
Title: Expression of Myh9 in the mammalian cochlea: localization within the stereocilia.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables P-type sodium:potassium-exchanging transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
contributes_to actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables follicle-stimulating hormone receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-membrane adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables scaffold protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament bundle distribution	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in actin filament capping	ISO Inferred from Sequence Orthology more info
NOT involved_in actin filament polymerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin filament-based movement	ISO Inferred from Sequence Orthology more info
involved_in actin filament-based movement	ISO Inferred from Sequence Orthology more info
involved_in actin filament-based movement	ISS Inferred from Sequence or Structural Similarity more info
involved_in actomyosin structure organization	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in blood vessel endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell motility	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell motility	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cortical granule exocytosis	IEA Inferred from Electronic Annotation more info
involved_in cortical granule exocytosis	ISO Inferred from Sequence Orthology more info
involved_in cortical granule exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytokinetic process	ISO Inferred from Sequence Orthology more info
involved_in cytokinetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in endodermal cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in establishment of T cell polarity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of T cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of meiotic spindle localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of meiotic spindle localization	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of transmembrane electrochemical gradient	IEA Inferred from Electronic Annotation more info
involved_in follicle-stimulating hormone signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in meiotic spindle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within meiotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein ectodomain proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in monocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in myoblast fusion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myoblast fusion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin filament severing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of actin filament severing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis, engulfment	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane repair	ISO Inferred from Sequence Orthology more info
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in platelet formation	ISO Inferred from Sequence Orthology more info
involved_in platelet formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inositol trisphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein processing in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein processing in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of plasma membrane repair	ISO Inferred from Sequence Orthology more info
involved_in uropod organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within uropod organization	ISO Inferred from Sequence Orthology more info
involved_in vesicle targeting	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in actomyosin	ISO Inferred from Sequence Orthology more info
located_in actomyosin contractile ring	ISO Inferred from Sequence Orthology more info
located_in actomyosin contractile ring	ISS Inferred from Sequence or Structural Similarity more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISS Inferred from Sequence or Structural Similarity more info
located_in cortical cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cortical granule	IEA Inferred from Electronic Annotation more info
located_in cortical granule	ISO Inferred from Sequence Orthology more info
located_in cortical granule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in exocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	IEA Inferred from Electronic Annotation more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IEA Inferred from Electronic Annotation more info
part_of myosin II complex	ISO Inferred from Sequence Orthology more info
located_in myosin II filament	ISO Inferred from Sequence Orthology more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
part_of myosin complex	ISO Inferred from Sequence Orthology more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in stress fiber	IEA Inferred from Electronic Annotation more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISS Inferred from Sequence or Structural Similarity more info
located_in uropod	IEA Inferred from Electronic Annotation more info
located_in uropod	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myosin-9

Names: myosin heavy chain 9-like 1; myosin, heavy chain 9, non-muscle-like 1; nonmuscle myosin IIA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305877.2 → NP_001292806.1 myosin-9

See identical proteins and their annotated locations for NP_001292806.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8J8XU90, A6HSG7

Related

ENSRNOP00000035440.6, ENSRNOT00000037611.7

Conserved Domains (3) summary

pfam01576
Location:842 → 1921

Myosin_tail_1; Myosin tail

pfam02736
Location:29 → 68

Myosin_N; Myosin N-terminal SH3-like domain

cl22853
Location:95 → 764

Motor_domain; Myosin and Kinesin motor domain
NM_013194.2 → NP_037326.2 myosin-9

See identical proteins and their annotated locations for NP_037326.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8J8XU90, A6HSG7

Conserved Domains (3) summary

pfam01576
Location:842 → 1921

Myosin_tail_1; Myosin tail

pfam02736
Location:29 → 68

Myosin_N; Myosin N-terminal SH3-like domain

cl22853
Location:95 → 764

Motor_domain; Myosin and Kinesin motor domain