U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    spsb4b splA/ryanodine receptor domain and SOCS box containing 4b [ Danio rerio (zebrafish) ]

    Gene ID: 445080, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    spsb4bprovided by ZNC
    Official Full Name
    splA/ryanodine receptor domain and SOCS box containing 4bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-213
    See related
    Ensembl:ENSDARG00000040538 AllianceGenome:ZFIN:ZDB-GENE-040801-213
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92395; wu:fd19a12
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within intracellular signal transduction. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See spsb4b in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (41670742..41689915, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (41713349..41732570, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101884422 Neighboring gene calsyntenin 2b Neighboring gene si:ch211-276c2.4 Neighboring gene E3 ubiquitin/ISG15 ligase TRIM25-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. foxl2 and foxl3 are two ancient paralogs that remain fully functional in teleosts. Crespo B, et al. Gen Comp Endocrinol, 2013 Dec 1. PMID 24045113
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    SPRY domain-containing SOCS box protein 4b

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003474.1 → NP_001003474.1  SPRY domain-containing SOCS box protein 4b

      See identical proteins and their annotated locations for NP_001003474.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078385
      UniProtKB/TrEMBL
      A0A2R8QAG8, F6P1H4, Q6DBS3
      Related
      ENSDARP00000151504.1, ENSDART00000187063.1
      Conserved Domains (2) summary
      cd03743
      Location:240 → 281
      SOCS_SSB4; SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for ...
      cd12906
      Location:57 → 235
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      41670742..41689915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157796.5 → XP_005157853.1  SPRY domain-containing SOCS box protein 4b isoform X1

      See identical proteins and their annotated locations for XP_005157853.1

      UniProtKB/TrEMBL
      A0A2R8QAG8, F6P1H4, Q6DBS3
      Related
      ENSDARP00000059326.4, ENSDART00000059327.7
      Conserved Domains (2) summary
      cd03743
      Location:240 → 281
      SOCS_SSB4; SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for ...
      cd12906
      Location:57 → 235
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

    2. XM_009291907.4 → XP_009290182.1  SPRY domain-containing SOCS box protein 4b isoform X1

      See identical proteins and their annotated locations for XP_009290182.1

      UniProtKB/TrEMBL
      A0A2R8QAG8, F6P1H4, Q6DBS3
      Conserved Domains (2) summary
      cd03743
      Location:240 → 281
      SOCS_SSB4; SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for ...
      cd12906
      Location:57 → 235
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

    3. XM_005157797.5 → XP_005157854.1  SPRY domain-containing SOCS box protein 4b isoform X1

      See identical proteins and their annotated locations for XP_005157854.1

      UniProtKB/TrEMBL
      A0A2R8QAG8, F6P1H4, Q6DBS3
      Conserved Domains (2) summary
      cd03743
      Location:240 → 281
      SOCS_SSB4; SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for ...
      cd12906
      Location:57 → 235
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

    4. XM_009291908.4 → XP_009290183.1  SPRY domain-containing SOCS box protein 4b isoform X1

      See identical proteins and their annotated locations for XP_009290183.1

      UniProtKB/TrEMBL
      A0A2R8QAG8, F6P1H4, Q6DBS3
      Conserved Domains (2) summary
      cd03743
      Location:240 → 281
      SOCS_SSB4; SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for ...
      cd12906
      Location:57 → 235
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.