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    lin7a lin-7 homolog A (C. elegans) [ Danio rerio (zebrafish) ]

    Gene ID: 393682, updated on 14-Nov-2024

    Summary

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    Official Symbol
    lin7aprovided by ZNC
    Official Full Name
    lin-7 homolog A (C. elegans)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1665
    See related
    Ensembl:ENSDARG00000013414 AllianceGenome:ZFIN:ZDB-GENE-040426-1665
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lin7b; zgc:73090
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in neurotransmitter secretion; regulation of synaptic assembly at neuromuscular junction; and synaptic vesicle transport. Predicted to be located in bicellular tight junction and plasma membrane. Predicted to be part of MPP7-DLG1-LIN7 complex. Predicted to be active in basolateral plasma membrane; cell-cell junction; and synapse. Is expressed in myotome and nervous system. Orthologous to human LIN7A (lin-7 homolog A, crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lin7a in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (21752320..21851473, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (22030787..22130520, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene myogenic factor 6 Neighboring gene microRNA mir-3906 Neighboring gene myogenic factor 5 Neighboring gene acyl-CoA synthetase short chain family member 3 Neighboring gene PTPRF interacting protein alpha 2 Neighboring gene uncharacterized LOC137491548 Neighboring gene LLP homolog, long-term synaptic facilitation factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of three zebrafish lin7 genes and their expression patterns in the retina. Wei X, et al. Exp Eye Res, 2006 Jan. PMID 16109407
    2. Zebrafish dou yan mutation causes patterning defects and extensive cell death in the retina. Catalano AE, et al. Dev Dyn, 2007 May. PMID 17436278, Free PMC Article
    3. Stepwise maturation of apicobasal polarity of the neuroepithelium is essential for vertebrate neurulation. Yang X, et al. J Neurosci, 2009 Sep 16. PMID 19759292, Free PMC Article
    4. Use of toxicogenomics to predict the potential toxic effect of Benzo(a)pyrene on zebrafish embryos: ocular developmental toxicity. Huang L, et al. Chemosphere, 2014 Aug. PMID 24875912
    5. An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in the brain of exposed zebrafish and their unexposed F2 offspring. Blanc M, et al. Sci Total Environ, 2021 Feb 1. PMID 32911150

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC73090

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein lin-7 homolog A
    Names
    neuroepithelial polarity protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200709.1 → NP_957003.1  protein lin-7 homolog A

      See identical proteins and their annotated locations for NP_957003.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059460
      UniProtKB/TrEMBL
      Q2M5E8, Q5TZ23, Q6PC63
      Related
      ENSDARP00000022617.8, ENSDART00000019748.9
      Conserved Domains (2) summary
      smart00569
      Location:16 → 69
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd00992
      Location:92 → 173
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      21752320..21851473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164866.5 → XP_005164923.1  protein lin-7 homolog A isoform X1

      UniProtKB/TrEMBL
      A0A8M2BC73
      Conserved Domains (2) summary
      smart00569
      Location:16 → 69
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd00992
      Location:92 → 173
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    Nucleotide Protein Strain
    Heading Accession and Version

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