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    dync2i2 dynein 2 intermediate chain 2 [ Danio rerio (zebrafish) ]

    Gene ID: 794361, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dync2i2provided by ZNC
    Official Full Name
    dynein 2 intermediate chain 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070928-9
    See related
    Ensembl:ENSDARG00000057635 AllianceGenome:ZFIN:ZDB-GENE-070928-9
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wdr34; dync2i1; zgc:171284
    Summary
    Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Acts upstream of or within intraciliary transport and neural tube development. Located in cilium. Is expressed in central nervous system; pronephric duct; and retina. Used to study neural tube defect. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 11 with or without polydactyly. Orthologous to human DYNC2I2 (dynein 2 intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dync2i2 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (13217896..13225402, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (13120908..13128414, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene si:dkey-228b2.6 Neighboring gene outer dense fiber of sperm tails 2a Neighboring gene spectrin alpha, non-erythrocytic 1 Neighboring gene uncharacterized LOC137488787 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1-like b Neighboring gene SET nuclear proto-oncogene b Neighboring gene adenosine A2a receptor b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways. Yin H, et al. J Hum Genet, 2020 Nov. PMID 32576942, Free PMC Article
    2. Retrograde intraflagellar transport by cytoplasmic dynein-2 is required for outer segment extension in vertebrate photoreceptors but not arrestin translocation. Krock BL, et al. Invest Ophthalmol Vis Sci, 2009 Nov. PMID 19474410, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways.
      Title: WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC171284

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intraciliary transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural tube development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in ciliary plasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic dynein 2 intermediate chain 2
    Names
    WD repeat domain 34
    dynein, cytoplasmic 2, intermediate chain 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105690.1 → NP_001099160.1  cytoplasmic dynein 2 intermediate chain 2

      See identical proteins and their annotated locations for NP_001099160.1

      Status: PROVISIONAL

      Source sequence(s)
      BC152526
      UniProtKB/TrEMBL
      A0A8M1NFY2, A7MD87
      Related
      ENSDARP00000074797.4, ENSDART00000080347.6
      Conserved Domains (2) summary
      COG2319
      Location:66 → 481
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:187 → 229
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      13217896..13225402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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