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    naga N-acetylgalactosaminidase, alpha [ Danio rerio (zebrafish) ]

    Gene ID: 560778, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nagaprovided by ZNC
    Official Full Name
    N-acetylgalactosaminidase, alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051113-256
    See related
    Ensembl:ENSDARG00000099313 AllianceGenome:ZFIN:ZDB-GENE-051113-256
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:123333
    Summary
    Predicted to enable alpha-galactosidase activity. Predicted to be involved in glycoside catabolic process and oligosaccharide metabolic process. Predicted to act upstream of or within carbohydrate metabolic process and lipid metabolic process. Predicted to be located in lysosome. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Kanzaki disease; Schindler disease type 1; angiokeratoma; and neuroaxonal dystrophy. Orthologous to human NAGA (alpha-N-acetylgalactosaminidase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See naga in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (985960..992148, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (972512..978700, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene ATP23 metallopeptidase and ATP synthase assembly factor homolog Neighboring gene RNA polymerase II associated protein 3 Neighboring gene glutamate receptor ionotropic, kainate 2 Neighboring gene protein FAM180A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of arsenic-exposed zebrafish (Danio rerio) identifies altered expression in proteins involved in fibrosis and lipid uptake in a gender-specific manner. Carlson P, et al. Toxicol Sci, 2013 Jul. PMID 23570992
    2. Pharmacological modulation of melanocortin-4 receptor by melanocortin receptor accessory protein 2 in Nile tilapia. Wang M, et al. Gen Comp Endocrinol, 2019 Oct 1. PMID 31299224
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123333

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alpha-galactosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycoside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-N-acetylgalactosaminidase
    NP_001032465.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037388.2 → NP_001032465.2  alpha-N-acetylgalactosaminidase precursor

      Status: VALIDATED

      Source sequence(s)
      EH434772, EH453970, EH479732, FO904962
      UniProtKB/TrEMBL
      A0A0R4IJL2, A0A8M1N7Y2
      Related
      ENSDARP00000134512.1, ENSDART00000160902.2
      Conserved Domains (1) summary
      cl07893
      Location:25 → 394
      AmyAc_family; Alpha amylase catalytic domain family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      985960..992148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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