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    aff3 AF4/FMR2 family, member 3 [ Danio rerio (zebrafish) ]

    Gene ID: 570215, updated on 14-Nov-2024

    Summary

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    Official Symbol
    aff3provided by ZNC
    Official Full Name
    AF4/FMR2 family, member 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030219-193
    See related
    Ensembl:ENSDARG00000079575 AllianceGenome:ZFIN:ZDB-GENE-030219-193
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    id:ibd5053; si:dkey-19j7.2
    Summary
    Predicted to be involved in regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of super elongation complex. Is expressed in notochord. Human ortholog(s) of this gene implicated in KINSSHIP syndrome. Orthologous to human AFF3 (ALF transcription elongation factor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See aff3 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (21490816..21526616, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (21679947..21715785, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene zinc finger, MYM-type 2 Neighboring gene M-phase phosphoprotein 8 Neighboring gene Rho guanine nucleotide exchange factor (GEF) 7a Neighboring gene uncharacterized LOC110438834

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes. Gui H, et al. Genome Biol, 2017 Mar 8. PMID 28274275, Free PMC Article
    2. Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish. Gomez G, et al. PLoS One, 2012. PMID 22438865, Free PMC Article
    3. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AF4/FMR2 family member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      21490816..21526616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478898.2 → XP_021334573.1  AF4/FMR2 family member 3

      UniProtKB/TrEMBL
      A0A8M3AW05
      Related
      ENSDARP00000113026.2, ENSDART00000137922.4
      Conserved Domains (1) summary
      pfam05110
      Location:730 → 1239
      AF-4; AF-4 proto-oncoprotein

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394750.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      50761..86561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009304671.3 → XP_009302946.1  AF4/FMR2 family member 3

      UniProtKB/TrEMBL
      A0A8M3AW05
      Conserved Domains (1) summary
      pfam05110
      Location:730 → 1239
      AF-4; AF-4 proto-oncoprotein
    Nucleotide Protein Strain
    Heading Accession and Version

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