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    odad4 outer dynein arm docking complex subunit 4 [ Danio rerio (zebrafish) ]

    Gene ID: 393286, updated on 2-Nov-2024

    Summary

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    Official Symbol
    odad4provided by ZNC
    Official Full Name
    outer dynein arm docking complex subunit 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-995
    See related
    Ensembl:ENSDARG00000058140 AllianceGenome:ZFIN:ZDB-GENE-040426-995
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ttc25; zgc:56362
    Summary
    Acts upstream of or within cilium assembly; determination of heart left/right asymmetry; and otolith morphogenesis. Predicted to be located in cell projection and cytoskeleton. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; forerunner cell group; otic placode; pronephric duct; and pronephric mesoderm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 35. Orthologous to human ODAD4 (outer dynein arm docking complex subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See odad4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (17910569..17928233)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (17760829..17778493)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene NFKB inhibitor interacting Ras-like 2 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 7 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene ATP citrate lyase a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function. Xu Y, et al. PLoS One, 2015. PMID 25860617, Free PMC Article
    2. Comparative analysis of the testis and ovary transcriptomes in zebrafish by combining experimental and computational tools. Li Y, et al. Comp Funct Genomics, 2004. PMID 18629171, Free PMC Article
    3. TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in zebrafish. Fillatre J, et al. Elife, 2019 Sep 12. PMID 31513014, Free PMC Article
    4. miR-34b regulates multiciliogenesis during organ formation in zebrafish. Wang L, et al. Development, 2013 Jul. PMID 23698347
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56362

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within determination of heart left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within otolith morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in outer dynein arm assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    outer dynein arm-docking complex subunit 4
    Names
    TPR repeat protein 25
    tetratricopeptide repeat domain 25
    tetratricopeptide repeat protein 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200316.1 → NP_956610.1  outer dynein arm-docking complex subunit 4

      See identical proteins and their annotated locations for NP_956610.1

      Status: PROVISIONAL

      Source sequence(s)
      BC051126
      UniProtKB/Swiss-Prot
      F1RBQ8, Q7ZU45
      Related
      ENSDARP00000075390.3, ENSDART00000080946.5
      Conserved Domains (3) summary
      sd00006
      Location:16 → 42
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:16 → 79
      TPR_11; TPR repeat
      pfam13424
      Location:355 → 423
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      17910569..17928233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZU45.2 GenPept UniProtKB/Swiss-Prot:Q7ZU45

    Gene LinkOut

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